CAJ | 학술논문

目的:探讨针刺对肥胖机体瘦素和胰岛素含量及其血脑转运的作用.方法:将1月龄刚断乳SD雄性大鼠分为正常组、针刺组和对照组,观察针刺治疗前后肥胖大鼠体质量、体脂及中枢和外周瘦素和胰岛素水平的变化.结果:肥胖大鼠体质量、体脂及血清瘦素和胰岛素水平均显著高于正常大鼠,而下丘脑瘦素和胰岛素水平均显著低于正常大鼠.针刺治疗取得良好减肥疗效的同时,针刺组肥胖大鼠血清瘦素和胰岛素水平[(13.43±1.85)μg/L,(66.92±24.71)mIU/L]与对照组[(17.23±3.07)μg/L,(172.40±74.99)mIU/L]比较,均明显回降(P＜0.05和0.01),而下丘脑瘦素和胰岛素水平却明显升高(P＜0.01和＜0.05).大鼠体质量与血中瘦素呈显著正相关(r=0.677,P＜0.01);血清瘦素与胰岛素含量呈明显正相关(r=0.538,P＜0.05).结论:针刺对肥胖机体下丘脑和血中瘦素和胰岛素水平的良性调整作用可能是改善瘦素抵抗和胰岛素抵抗以及调整异常的内分泌代谢的一个重要环节.这种作用可能是针刺减肥的关键因素之一.
목적:탐토침자대비반궤체수소화이도소함량급기혈뇌전운적작용.방법:장1월령강단유SD웅성대서분위정상조、침자조화대조조,관찰침자치료전후비반대서체질량、체지급중추화외주수소화이도소수평적변화.결과:비반대서체질량、체지급혈청수소화이도소수평균현저고우정상대서,이하구뇌수소화이도소수평균현저저우정상대서.침자치료취득량호감비료효적동시,침자조비반대서혈청수소화이도소수평[(13.43±1.85)μg/L,(66.92±24.71)mIU/L]여대조조[(17.23±3.07)μg/L,(172.40±74.99)mIU/L]비교,균명현회강(P＜0.05화0.01),이하구뇌수소화이도소수평각명현승고(P＜0.01화＜0.05).대서체질량여혈중수소정현저정상관(r=0.677,P＜0.01);혈청수소여이도소함량정명현정상관(r=0.538,P＜0.05).결론:침자대비반궤체하구뇌화혈중수소화이도소수평적량성조정작용가능시개선수소저항화이도소저항이급조정이상적내분비대사적일개중요배절.저충작용가능시침자감비적관건인소지일.
AIM: To explore the effect of acupuncture on the contents and blood-brain transport of leptin and insulin in obese organism.METHODS: Male SD rats, one-month old, were divided into normal group,acupuncture group and control group. The changes of body mass, body fat, the level of central and peripheral serum leptin and insulin in obese rats were observed before and after acupuncture.RESULTS: The body mass, body fat, the level of serum leptin and insulin in the obese rats were all markedly higher than those in the normal rats, but the levels of hypothalamic leptin and insulin in obese rats were all lower than those of normal rats. After acupuncture treatment, the marked losing effect of body mass was achieved, the levels of serum leptin and insulin in the acupuncture group[(13.43 + 1.85) μg /L, (66.92+24.71) mIU/L]were obviously decreased compared with those in the control group [(17.23+3.07) μg /L, (172.40+74.99) mIU/L] (P ＜0.05,0.01),while the levels of hypothalamic leptin and insulin in the acupuncture group and the control group were all obviously increased( P ＜ 0.01, P ＜ 0.05).There was significantly positive correlation between body mass and serum leptin ( r = 0.677, P ＜ 0.01 ), and obviously positive correlation between serum leptin and insulin( r =0. 538, P ＜ 0.05).CONCLUSION: The good regulation of acupuncture on levels of hypothalamic and serum leptin and insulin possibly is an important link in improving the resistance of leptin and insulin as well as regulation abnormal metabolism in obese organism. The effective regulation is possibly the key factors in the anti-obesity of acupuncture.