创伤性脓毒症过程中外周血PMN及组织中ICE mRNA表达的变化
창상성농독증과정중외주혈PMN급조직중ICE mRNA표체적변화
The changes of ICE mRNA expression in systemic blood PMNs and tissues during tramatic sepsis
  • 万方数据
    军医进修学院学报 군의진수학원학보
    ACADEMIC JOURNAL OF PLA POSTGRADUATE MEDICAL SCHOOL
    2005年 5期 360-361 ,共2页

    隰建成%马远征%周宝桐%常国友%马诺山%陆连荣%郭振荣%盛志勇

    습건성%마원정%주보동%상국우%마낙산%륙련영%곽진영%성지용

    脓毒症%白细胞介素1β转换酶%创伤和损伤 膿毒癥%白細胞介素1β轉換酶%創傷和損傷
    농독증%백세포개소1β전환매%창상화손상
    目的:探讨盲肠结扎穿孔术(CLP)后大鼠外周血多形核白细胞(polymorphonuclear leukocyte,PMN)及组织中白细胞介素1β转换酶(interleukin-1β converting enzyme,ICE,现称caspase 1)mRNA表达的变化规律.方法:采用逆转录多聚酶链式反应(reverse transcription-polymerase chain reaction,RT-PCR)检测大鼠外周血PMN及组织中ICE mRNA的表达.结果:CLP术后循环血中多形核白细胞(PMN)中ICE mRNA表达逐渐增高,达峰值后开始降低,但仍明显高于正常.ICE mRNA表达的增高首先出现于血PMN中,迟后转移至肺、小肠和肝组织中.结论:ICE mRNA表达的增高在脓毒症的发病机制中起着重要的作用.
    목적:탐토맹장결찰천공술(CLP)후대서외주혈다형핵백세포(polymorphonuclear leukocyte,PMN)급조직중백세포개소1β전환매(interleukin-1β converting enzyme,ICE,현칭caspase 1)mRNA표체적변화규률.방법:채용역전록다취매련식반응(reverse transcription-polymerase chain reaction,RT-PCR)검측대서외주혈PMN급조직중ICE mRNA적표체.결과:CLP술후순배혈중다형핵백세포(PMN)중ICE mRNA표체축점증고,체봉치후개시강저,단잉명현고우정상.ICE mRNA표체적증고수선출현우혈PMN중,지후전이지폐、소장화간조직중.결론:ICE mRNA표체적증고재농독증적발병궤제중기착중요적작용.
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