CAJ | 학술논문

目的:探讨早产儿尿S100B水平的变化及其与早产儿早期脑损伤的关系.方法 :将新生儿分别于生后24 h及120 h留尿测定S100B水平,其中84例住院早产儿和26例足月儿(对照组),观察患儿临床表现并进行头颅B超检查,对各胎龄组早产儿尿S100B水平及脑损伤进行评估.结果:各无脑损伤胎龄组生后24 h及120 h尿S100B水平差异具有统计学意义,随胎龄增加呈下降趋势.早产儿脑室周围脑室内出血(PIVH) 27 例,其24 h及120 h尿S100B水平均高于无脑损伤组(P ＜ 0.05);红细胞增多症10例,头颅B超未见异常,但尿S100B水平高于无脑损伤组;脑室周围白质软化(PVL)3例,尿S100B升高.早产儿痊愈54例, 好转27例, 恶化及死亡3例,病情恶化及死亡者尿S100B值高于痊愈和好转患儿.结论:测定早产儿尿S100B水平可早期发现PIVH、PVL及其高度可疑病例,应进一步检查并予以保护性治疗并加强随访.
목적:탐토조산인뇨S100B수평적변화급기여조산인조기뇌손상적관계.방법 :장신생인분별우생후24 h급120 h류뇨측정S100B수평,기중84례주원조산인화26례족월인(대조조),관찰환인림상표현병진행두로B초검사,대각태령조조산인뇨S100B수평급뇌손상진행평고.결과:각무뇌손상태령조생후24 h급120 h뇨S100B수평차이구유통계학의의,수태령증가정하강추세.조산인뇌실주위뇌실내출혈(PIVH) 27 례,기24 h급120 h뇨S100B수평균고우무뇌손상조(P ＜ 0.05);홍세포증다증10례,두로B초미견이상,단뇨S100B수평고우무뇌손상조;뇌실주위백질연화(PVL)3례,뇨S100B승고.조산인전유54례, 호전27례, 악화급사망3례,병정악화급사망자뇨S100B치고우전유화호전환인.결론:측정조산인뇨S100B수평가조기발현PIVH、PVL급기고도가의병례,응진일보검사병여이보호성치료병가강수방.
Objective: To investigate the changes of urinary S100B protein concentrations and their relationship with brain damage in preterm infants there of . Methods: The urinary S100B protein of 84 preterm infants and 26 full term infants, which were used as control, were measured at 24 h and 120 h after birth. At the same time, routine clinical observations, neurologic patterns and ultrasound screens were recorded. The value of urinary S100B protein and brain damage were evaluated in preterm infants with different gestational age. Results: The differences of urinary S100B protein were statistical significance between the different gestations. The levels of urinary S100B protein were higher in preterm infants, whose gestations were lower than 32 W, than those of other groups. The levels of S100B protein were significantly higher in samples of 27 peri-intraventricular hemorrhage (PIVH) and 3 peri-ventricular leukomalacia(PVL) than those in samples without brain damage( P ＜ 0.05). The S100B levels were significantly higher in urine of 10 preterm infants with polycethemia than those in infants without brain damages. In addition, the S100B levels were different in urine of preterm infants with different prognosis. The S100B levels were significantly higher in urine of infants who died or deteriorated than those of others(P ＜ 0.05). Conclusion: There is an evident trend of decrease in urinary S100B protein concentration with increasing gestational age. It will be helpful to identify preterm infants with PIVH,PVL and high risk of brain damages by measurement of S100B protein in urine early after birth, which indicates further inspection, provides protective treatment and enhances follow up.