CAJ | 학술논문

目的研究大鼠股骨骨折合并脑外伤时胰岛素样生长因子-Ⅰ(Instdin-like Growth Factor-Ⅰ IGF-Ⅰ)在骨痂中的表达,探讨骨折合并脑外伤骨折愈合加快的机制.方法 12周雄性Sprague-Daw-Iey大鼠16只,随机分成8组,每组8只,即:2周单纯骨折组(G1)、2周骨折合并脑外伤组(G2).建立大鼠脑外伤和骨折模型.分别于2周取材,骨痂作SP法免疫组化染色.结果免疫组化分析平均阳性细胞百分数骨折合并脑外伤组高于单纯骨折组.结论脑外伤对骨折愈合有促进作用,IGF-Ⅰ可能是脑外伤促进骨折愈合的原因.
목적 연구대서고골골절합병뇌외상시이도소양생장인자-Ⅰ(Instdin-like Growth Factor-Ⅰ IGF-Ⅰ)재골가중적표체,탐토골절합병뇌외상골절유합가쾌적궤제.방법 12주웅성Sprague-Daw-Iey대서16지,수궤분성8조,매조8지,즉:2주단순골절조(G1)、2주골절합병뇌외상조(G2).건립대서뇌외상화골절모형.분별우2주취재,골가작SP법면역조화염색.결과 면역조화분석평균양성세포백분수골절합병뇌외상조고우단순골절조.결론 뇌외상대골절유합유촉진작용,IGF-Ⅰ가능시뇌외상촉진골절유합적원인.
Objective To investigate the expression of Insulin-llke Growth Factor- Ⅰ in s callus of rats with femoral fracture and brain injury, and study the mechanism of enhanced osteogenesis after brain injury. Methods Sixteen 12-week-old Sprague-Dawley rats were randomly divided into eight groups with eight animals of each,the fracture without brain injury group in two weeks(G1)、the fracture with brain injury group in two weeks(G2)、 Fracture and brain injury models were established. The rats were sacrificed in two weeks respectively after operation. The callus were examed with immuhistochemical staining (SP). Results Percent positive cells(%) in callus of the fracture with brain injury group is higher than that of the fracture without brain injury group. Conclusion The brain injury can enhance the fracture healing and IGF- Ⅰ may be the reason of enhanced osteogenesis.