CAJ | 학술논문

目的通过检测血清及胸水中可溶性Apo-1/Fas(sApo-1/Fas)的水平,探讨其对鉴别良恶性疾病的意义.方法采用酶联免疫吸附法(ELISA)法检测50例恶性胸腔积液患者和48例结核性胸腔积液患者血清和胸水中sApo-1/Fas的含量.结果恶性胸腔积液患者血清和胸水中sApo-1/Fas的含量分别为(16.3±2.5)μg/L、(38.6±13.5) μg/L,均明显高于结核性胸腔积液组(均P＜0.05).两组胸水/血清sApo-1/Fas比值差异有统计学意义(P＜0.05).血清sApo-1/Fas+胸水sApo-1/Fas对恶性胸腔积液诊断的敏感度为66.0％、特异度为93.8％、准确度为79.6％.结论血清和胸水中sApo-1/Fas的测定有利于良恶性胸水的鉴别.
목적 통과검측혈청급흉수중가용성Apo-1/Fas(sApo-1/Fas)적수평,탐토기대감별량악성질병적의의.방법 채용매련면역흡부법(ELISA)법검측50례악성흉강적액환자화48례결핵성흉강적액환자혈청화흉수중sApo-1/Fas적함량.결과 악성흉강적액환자혈청화흉수중sApo-1/Fas적함량분별위(16.3±2.5)μg/L、(38.6±13.5) μg/L,균명현고우결핵성흉강적액조(균P＜0.05).량조흉수/혈청sApo-1/Fas비치차이유통계학의의(P＜0.05).혈청sApo-1/Fas+흉수sApo-1/Fas대악성흉강적액진단적민감도위66.0％、특이도위93.8％、준학도위79.6％.결론 혈청화흉수중sApo-1/Fas적측정유리우량악성흉수적감별.
Objective To investigate the significance of the soluble Apo-1/Fas(sApo-1/Fas) in differentiating tuberculous and malignant pleural effusion.Methods The level of sApo-1/Fas was detected by enzyme linked immunosorbent assay(ELISA).in serum and pleural effusion of 50 cases with malignant pleural effusion and 48 cases with tuberculous pleural effusion.Results The level of sApo-1/Fas in the serum and pleural effusion of malignant pleural effusion patients were ( 16.3 ± 2.5 ) μg/L and ( 38.6 ± 13.5) μg/L,significantly higher than those of tuberculous patients with pleural effusion( all P ＜ 0.05 ).The difference of rates of serum and pleural effusion in malignant pleural effusion and tuberculous pleural effusion patients was significant( P ＜ 0.05 ).The sensitivity,specificity and accuracy of sApo-1/Fas in serum and malignant pleural effusion were 66.0％ and 93.8％ and 79.6％.Conclusion The detecting of sApo-1/Fas may play some role in differentiating tuberculous and malignant pleural effusion.