中华核医学杂志
中華覈醫學雜誌
중화핵의학잡지
CHINESE JOURNAL OF NUCLEAR MEDICINE
2011年
5期
293-296
,共4页
邱春%管一晖%陈丽敏%孙伯民%李殿友%黄喆慜%赵军%左传涛
邱春%管一暉%陳麗敏%孫伯民%李殿友%黃喆慜%趙軍%左傳濤
구춘%관일휘%진려민%손백민%리전우%황철민%조군%좌전도
强迫性障碍%脑%体层摄影术,发射型计算机%脱氧葡萄糖
彊迫性障礙%腦%體層攝影術,髮射型計算機%脫氧葡萄糖
강박성장애%뇌%체층섭영술,발사형계산궤%탈양포도당
Obsessive-oompulsive disorder%Brain%Tomography,emission-computed%Deoxyglucose
目的 应用18F-FDG PET显像研究难治性强迫症脑内葡萄糖异常代谢区域,为临床诊疗提供客观的影像学依据.方法 对8例难治性强迫症患者和8名健康对照者进行脑18F-FDG PET显像,利用SPM软件进行对比,分析强迫症患者葡萄糖代谢改变的脑区,并对代谢变化与Yale-Brown 强迫症评定量表(Y-BOCS)评分进行相关性研究.结果 难治性强迫症患者双侧额叶皮质(包括直回、眶回及扣带回)、左侧丘脑、右侧颞叶、双侧小脑葡萄糖代谢高于健康对照组(Zmax =3.45 ~5.80,P均<0.001);而双侧额叶运动区皮质及双侧顶叶(BA7)呈低代谢(Zmax=3.44~4.46,P均<0.001).Y-BOCS评分与双侧前扣带回皮质葡萄糖代谢呈正相关(Zmax=3.77,3.48,2.97,P均<0.01).结论 难治性强迫症患者脑内额叶-纹状体-丘脑-额叶环路葡萄糖代谢增高,同时伴随双侧额叶运动区皮质及顶叶葡萄糖代谢减低;前扣带回葡萄糖代谢状态有助于评价强迫症病情的严重程度.
目的 應用18F-FDG PET顯像研究難治性彊迫癥腦內葡萄糖異常代謝區域,為臨床診療提供客觀的影像學依據.方法 對8例難治性彊迫癥患者和8名健康對照者進行腦18F-FDG PET顯像,利用SPM軟件進行對比,分析彊迫癥患者葡萄糖代謝改變的腦區,併對代謝變化與Yale-Brown 彊迫癥評定量錶(Y-BOCS)評分進行相關性研究.結果 難治性彊迫癥患者雙側額葉皮質(包括直迴、眶迴及釦帶迴)、左側丘腦、右側顳葉、雙側小腦葡萄糖代謝高于健康對照組(Zmax =3.45 ~5.80,P均<0.001);而雙側額葉運動區皮質及雙側頂葉(BA7)呈低代謝(Zmax=3.44~4.46,P均<0.001).Y-BOCS評分與雙側前釦帶迴皮質葡萄糖代謝呈正相關(Zmax=3.77,3.48,2.97,P均<0.01).結論 難治性彊迫癥患者腦內額葉-紋狀體-丘腦-額葉環路葡萄糖代謝增高,同時伴隨雙側額葉運動區皮質及頂葉葡萄糖代謝減低;前釦帶迴葡萄糖代謝狀態有助于評價彊迫癥病情的嚴重程度.
목적 응용18F-FDG PET현상연구난치성강박증뇌내포도당이상대사구역,위림상진료제공객관적영상학의거.방법 대8례난치성강박증환자화8명건강대조자진행뇌18F-FDG PET현상,이용SPM연건진행대비,분석강박증환자포도당대사개변적뇌구,병대대사변화여Yale-Brown 강박증평정량표(Y-BOCS)평분진행상관성연구.결과 난치성강박증환자쌍측액협피질(포괄직회、광회급구대회)、좌측구뇌、우측섭협、쌍측소뇌포도당대사고우건강대조조(Zmax =3.45 ~5.80,P균<0.001);이쌍측액협운동구피질급쌍측정협(BA7)정저대사(Zmax=3.44~4.46,P균<0.001).Y-BOCS평분여쌍측전구대회피질포도당대사정정상관(Zmax=3.77,3.48,2.97,P균<0.01).결론 난치성강박증환자뇌내액협-문상체-구뇌-액협배로포도당대사증고,동시반수쌍측액협운동구피질급정협포도당대사감저;전구대회포도당대사상태유조우평개강박증병정적엄중정도.
Objective To investigate the glucose metabolic pattern of brain functional loop in patients with refractory obsessive compulsive disorder (OCD) using 18 F-FDG PET.Methods Eight patients with refractory OCD and 8 age- and gender-matched healthy volunteers underwent 18F-FDG PET brain imaging.SPM software was used for image post-processing and quantitative analysis.Correlation analysis between 18F-FDG uptake and Yale-Brown obsessive compulsive scale(Y-BOCS) score was performed.Results Compared with the controls,the glucose metabolism of bilateral frontal cortices ( including the rectal gyrus,orbital gyrus and cingulate gyrus),left thalamus,right temporal lobe and bilateral cerebellum in refractory OCD patients increased significantly ( Zmax =3.45 - 5.80,all P < 0.001 ).Bilateral motor cortices and bilateral parietal lobes (BA7),however,showed decreased glucose metabolism (Zmax =3.44 - 4.46,all P <0.001 ).Y-BOCS score was positively correlated with the glucose metabolism of the bilateral anterior cingulate cortex (Zmax =3.77,3.48 and 2.97,all P < 0.01 ).Conclusions There is a characteristic metabolic pattern of increased glucose utilization in the fronto-striato-thalamic loop and decreased glucose utilization in bilateral motor cortices and parietal lobes in patients with OCD.The glucose metabolism in the anterior cingulate cortex might serve as a quantitative parameter for the assessment of the severity of OCD.