国际外科学杂志
國際外科學雜誌
국제외과학잡지
INTERNATIONAL JOURNAL OF SURGERY
2009年
3期
171-174
,共4页
高伟%陈为艳%张宝泉%杨新刚%王守峰%党正杰
高偉%陳為豔%張寶泉%楊新剛%王守峰%黨正傑
고위%진위염%장보천%양신강%왕수봉%당정걸
烧伤%残余创面%复合溶葡萄球菌酶%创面感染
燒傷%殘餘創麵%複閤溶葡萄毬菌酶%創麵感染
소상%잔여창면%복합용포도구균매%창면감염
burns%residual wounds%compound lysostaphin%wound infection
目的 观察复合溶葡萄球菌酶消毒剂在治疗烧伤后期创面感染的疗效和安全性,评价其临床应用价值.方法 对入选的60例烧伤后期创面感染患者,采用随机分组,在常规治疗的基础上,治疗组入院后创面应用复合溶葡萄球菌酶消毒剂(上海高科生物工程有限公司生产)溶液清创并湿敷,1次/d;对照组以庆大霉素+0.9%氯化钠注射液纱布湿敷,1次/d.2组创面清洁后40例行清创植皮,治疗组及对照组各20例.检测创面菌群变化,比较两组累计细菌清除率、创面愈合时间及愈合率.结果 治疗组用药后3、6、9d累计细菌清除率为45.8%、73.9%、89.5%,较对照组13.8%、27.6%、57.4%明硅增高(P＜0.01).创面愈合时间治疗组(12±5)d,较对照组(16±4)d明显缩短(P＜0.01).创丽愈合率治疗组明显高于对照组(P＜0.01).用药后均未发现不良反应.结论 烧伤后期创面感染应用复合溶葡萄球菌酶消毒剂治疗,有效地控制了感染、提高了植皮成活率、缩短了创面愈合时间,安全有效.
目的 觀察複閤溶葡萄毬菌酶消毒劑在治療燒傷後期創麵感染的療效和安全性,評價其臨床應用價值.方法 對入選的60例燒傷後期創麵感染患者,採用隨機分組,在常規治療的基礎上,治療組入院後創麵應用複閤溶葡萄毬菌酶消毒劑(上海高科生物工程有限公司生產)溶液清創併濕敷,1次/d;對照組以慶大黴素+0.9%氯化鈉註射液紗佈濕敷,1次/d.2組創麵清潔後40例行清創植皮,治療組及對照組各20例.檢測創麵菌群變化,比較兩組纍計細菌清除率、創麵愈閤時間及愈閤率.結果 治療組用藥後3、6、9d纍計細菌清除率為45.8%、73.9%、89.5%,較對照組13.8%、27.6%、57.4%明硅增高(P＜0.01).創麵愈閤時間治療組(12±5)d,較對照組(16±4)d明顯縮短(P＜0.01).創麗愈閤率治療組明顯高于對照組(P＜0.01).用藥後均未髮現不良反應.結論 燒傷後期創麵感染應用複閤溶葡萄毬菌酶消毒劑治療,有效地控製瞭感染、提高瞭植皮成活率、縮短瞭創麵愈閤時間,安全有效.
목적 관찰복합용포도구균매소독제재치료소상후기창면감염적료효화안전성,평개기림상응용개치.방법 대입선적60례소상후기창면감염환자,채용수궤분조,재상규치료적기출상,치료조입원후창면응용복합용포도구균매소독제(상해고과생물공정유한공사생산)용액청창병습부,1차/d;대조조이경대매소+0.9%록화납주사액사포습부,1차/d.2조창면청길후40례행청창식피,치료조급대조조각20례.검측창면균군변화,비교량조루계세균청제솔、창면유합시간급유합솔.결과 치료조용약후3、6、9d루계세균청제솔위45.8%、73.9%、89.5%,교대조조13.8%、27.6%、57.4%명규증고(P＜0.01).창면유합시간치료조(12±5)d,교대조조(16±4)d명현축단(P＜0.01).창려유합솔치료조명현고우대조조(P＜0.01).용약후균미발현불량반응.결론 소상후기창면감염응용복합용포도구균매소독제치료,유효지공제료감염、제고료식피성활솔、축단료창면유합시간,안전유효.
Objective To investigate the efficacy and safety of compound lysostaphin disinfectant solution in the latter stage of the treatment of bum wounds infection,and to evaluate its clinical value.Methods The selected 60 cases of bum wound infection were grouped into treatment and control group at random.The treatment group recieved compound lysostaphin disinfectant solution(Shanghai Hi-tech Co.bio-engineering,Ltd.)with debridement and wet,once a day;the control group with normal saline+gentamicin wet gauze,once a day.After cleaning the wound two groups 40 cases of underwent regular skin debridement,20 cases in each group.The bacteria changes in the wound were detected,of bacteria removal the accumulated rate of wound healing time and healing rate were compared.Results 3,6,9 days after treatment the accumulated rate of bacteria removal was 45.8%,73.9%, 89.5%higherthan the control group(13.8%,27.6%,57.4%)respectively(P＜0.01).Wound healing time in the treatment group was(12±5)d,shorter than the control group(16±4)d Was significantly(P＜0.01). The rate of wound healing in the treatment group was significantly higher(P＜0.01).No adverse reactions were found.Conclusion The treatment application of compound iysostaphin disinfectant in the later stage of bum wound is effective in control of infection,increases the survival rate of skin and shortens wound healing time,so it is safe and effective.
