中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2012年
4期
505-506
,共2页
辛伐他汀%低分子肝素%不稳定性,心绞痛%Meta分析
辛伐他汀%低分子肝素%不穩定性,心絞痛%Meta分析
신벌타정%저분자간소%불은정성,심교통%Meta분석
Simvastatin%Low molecular weight heparin%Unstable angina%Meta Analysis
目的 系统评价辛伐他汀联合低分子肝素治疗不稳定型心绞痛的效果.方法 检索万方医学网、中国期刊全文数据库(CNKI)、重庆维普(VIP)、PubMed数据库中有关辛伐他汀联合低分子肝素治疗不稳定型心绞痛的文献,对纳入的15项随机对照试验(共1206名患者)进行Meta分析.结果 采用固定效应模型对两组总体有效率比较:x2 =2.62,综合RR=1.30(95％ CI:1.23 ～1.38);采用随机效应模型对两组治疗后发作次数比较:x2=1231.87,加权均数差=-2.68(-5.82,0.5)；采用随机效应模型对两组治疗后发作持续时间进行比较:x2=1231.87,加权均数差=-2.68(-5.82,0.5).结论 辛伐他汀联用低分子肝素能够提高不稳定型心绞痛的总体有效率,不能降低治疗后的发作次数,但能减少每次发作后持续的时间.
目的 繫統評價辛伐他汀聯閤低分子肝素治療不穩定型心絞痛的效果.方法 檢索萬方醫學網、中國期刊全文數據庫(CNKI)、重慶維普(VIP)、PubMed數據庫中有關辛伐他汀聯閤低分子肝素治療不穩定型心絞痛的文獻,對納入的15項隨機對照試驗(共1206名患者)進行Meta分析.結果 採用固定效應模型對兩組總體有效率比較:x2 =2.62,綜閤RR=1.30(95％ CI:1.23 ～1.38);採用隨機效應模型對兩組治療後髮作次數比較:x2=1231.87,加權均數差=-2.68(-5.82,0.5)；採用隨機效應模型對兩組治療後髮作持續時間進行比較:x2=1231.87,加權均數差=-2.68(-5.82,0.5).結論 辛伐他汀聯用低分子肝素能夠提高不穩定型心絞痛的總體有效率,不能降低治療後的髮作次數,但能減少每次髮作後持續的時間.
목적 계통평개신벌타정연합저분자간소치료불은정형심교통적효과.방법 검색만방의학망、중국기간전문수거고(CNKI)、중경유보(VIP)、PubMed수거고중유관신벌타정연합저분자간소치료불은정형심교통적문헌,대납입적15항수궤대조시험(공1206명환자)진행Meta분석.결과 채용고정효응모형대량조총체유효솔비교:x2 =2.62,종합RR=1.30(95％ CI:1.23 ～1.38);채용수궤효응모형대량조치료후발작차수비교:x2=1231.87,가권균수차=-2.68(-5.82,0.5)；채용수궤효응모형대량조치료후발작지속시간진행비교:x2=1231.87,가권균수차=-2.68(-5.82,0.5).결론 신벌타정련용저분자간소능구제고불은정형심교통적총체유효솔,불능강저치료후적발작차수,단능감소매차발작후지속적시간.
Objective To assess the curative effects of simvastatin combine with low molecular weight heparin in patient with unstable angina.Methods The papers from China Academic Journal ( CNKI),Chongqing VIP (VIP),PubMed database were retrieved by computer,15 randomized controlled trials( 1206 patients) were included for Meta-analysis.Results The overall efficiency of the two groups were compared by Fixed effects model:x2 =2.62,Consolidated RR =1.30 (95％ CI:1.23 ～ 1.38 ) ; the number of attacks after treatment of the two groups were compared by random effects model:x2 =1231.87,WMD =- 2.68 ( - 5.82,0.5 ) ; the duration time of attacks after treatment in both groups were compared by random effects model:x2 =1231.87,weighted mean difference =-2.68(-5.82,0.5).Conclusion Simvastatin combine with low molecular weight heparin could improve the overall efficiency on patient with unstable angina,and could not reduce the number of attacks after treatment,but could reduce the duration time of attacks after the treatment.
