CAJ | 학술논문

目的研究18F-脱氧葡萄糖(FDG)PET/CT显像对甲状腺偶发瘤的检出率及检出恶性病灶的比例、最大标准摄取值(SUVmax)对鉴别诊断良、恶性病变的价值.方法回顾性分析2007年6月-2008年1月1190例无甲状腺癌病史的PET/CT受检者资料,对PET/CT发现的甲状腺偶发瘤行定性、半定量分析.对数据行Kruskal-Wallis检验或Spearman相关分析.结果 18F-FDG PET/CT全身显像对甲状腺偶发瘤的检出率为2.1%(25/1190),其中20例取得病理结果,良性病变9例,恶性病变11例(9例乳头状癌、1例滤泡状癌、1例肺癌转移),恶性比例高达55%(11/20).良、恶性病变组间SUVmax差异有统计学意义(分别为4.1±1.9和13.3±11.8,x2=8.8,P<0.01).甲状腺偶发瘤最大径(1.0-4.2 cm)与其18F-FDG摄取(SUVmax为3.0-46.0)之间无相关性(r=0.25,P>0.O1).结论 18F-FDG PET/CT检查发现甲状腺偶发瘤中甲状腺癌比例很高,其SUV一对鉴别诊断良、恶性病变有参考价值.
목적 연구18F-탈양포도당(FDG)PET/CT현상대갑상선우발류적검출솔급검출악성병조적비례、최대표준섭취치(SUVmax)대감별진단량、악성병변적개치.방법 회고성분석2007년6월-2008년1월1190례무갑상선암병사적PET/CT수검자자료,대PET/CT발현적갑상선우발류행정성、반정량분석.대수거행Kruskal-Wallis검험혹Spearman상관분석.결과 18F-FDG PET/CT전신현상대갑상선우발류적검출솔위2.1%(25/1190),기중20례취득병리결과,량성병변9례,악성병변11례(9례유두상암、1례려포상암、1례폐암전이),악성비례고체55%(11/20).량、악성병변조간SUVmax차이유통계학의의(분별위4.1±1.9화13.3±11.8,x2=8.8,P<0.01).갑상선우발류최대경(1.0-4.2 cm)여기18F-FDG섭취(SUVmax위3.0-46.0)지간무상관성(r=0.25,P>0.O1).결론 18F-FDG PET/CT검사발현갑상선우발류중갑상선암비례흔고,기SUV일대감별진단량、악성병변유삼고개치.
Objective 18F-fluorodeoxyglucose(FDG)PET/CT is a noninvasive whole-body ima-ging technique used to evaluate various types of malignancies.Recent advances have rapidly developed it in-to a diagnostic imaging modality in ontology.The aims of this study were two.One was to estimate the de-tection rate of thyroid incidentaloma and the risk of thyroid malignancy by 18F-FDG PET/CT scan and the other Was to further understand whether the maximum standardized uptake value(SUVmax)would be helpful in differentiating benign from malignant thyroid tumor.Methods From June 2007 to January 2008,a total of 1190 subjects who had no previous history of thyroid cancer and had 18F-FDG PET/CT scan were includ-ed.All had visual interpretation and semiquantitative analyses by SUVmax at thyroid incidentalomas detected by FDG PET/CT.Kruskal-Wallis test and Spearman relation analysis were used.Results The prevalence of thyroid incidentaloma on 18F-FDG PET/CT wag 2.1%(25/1190).Of these 25 tumors,20 had histologi-cally proven.Of these 20 tumors,9 were benign and 11 were malignant(papillary carcinoma of thyroid gland in 9,follicular carcinoma of thyroid gland in I,metastatic squamous cell carcinoma from lung cancer in 1).Therefore,the cancer risk of thyroid incidentaloma was 55%(11/20).Significantly higher SUVmax in malignant than in benign nodules were observed(Kruskal-Wallis test,X2=8.8,P<O.01).However,the correlation between SUVmax(3.0-46.0)and maximal diameter(1.O-4.2cm)of nodule findings was insignificant(r=0.25,P>0.01).Conclusion Thyroid incidentaloma detected by 18F-FDG PET/CT has higher risk rate for thyroid malignancy.