CAJ | 학술논문

人类基因组序列的研究成功,为基因组功能分析奠定基础.而DNA芯片技术允许同时检测上千个基因,成为基因组功能分析的方法之一.从正常的黑素细胞、非典型痣、原位黑素瘤到侵袭性黑素瘤的发展过程,使恶性黑素瘤成为使用DNA芯片技术研究肿瘤发病机制的模型.使用DNA芯片技术根据恶性黑素瘤基因表达谱的不同,对恶性黑素瘤进行新的分型,发现恶性黑素瘤形成过程中的基因表达异常、染色体变异及与恶性黑素瘤转移相关的基因等.
인류기인조서렬적연구성공,위기인조공능분석전정기출.이DNA심편기술윤허동시검측상천개기인,성위기인조공능분석적방법지일.종정상적흑소세포、비전형지、원위흑소류도침습성흑소류적발전과정,사악성흑소류성위사용DNA심편기술연구종류발병궤제적모형.사용DNA심편기술근거악성흑소류기인표체보적불동,대악성흑소류진행신적분형,발현악성흑소류형성과정중적기인표체이상、염색체변이급여악성흑소류전이상관적기인등.
The Successful scquencing of whole human genome provides a substantial basis for the research of gene function.DNA chip technology allows the simultaneous detection of thousands of genes,and has developed into a key method for functional genomics.The charaeteristic stepwise progression from normal pigment cells to atypical nevi.then to invasive primary melanoma and finally to cells with aggressive metastatic potential makes human melanoma an ideal tumor model for the studv of human tumorigenesis.Based on the difference in gene expression profile in malignant melanoma,DNA chip technology could be applied to classify malignant melanoma.observe the abnormality in gene expression and chromosome in the development of malignant melanoma,and to detect malignant melanoma-related genes.