中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2010年
10期
1413-1414,后插一
,共3页
徐哲%管洪宇%费迎春%李作青%李穗生%潘翠玲%刘钧澄
徐哲%管洪宇%費迎春%李作青%李穗生%潘翠玲%劉鈞澄
서철%관홍우%비영춘%리작청%리수생%반취령%류균징
鞘氨醇激酶1%神经母细胞瘤%表达
鞘氨醇激酶1%神經母細胞瘤%錶達
초안순격매1%신경모세포류%표체
Sphingolipids kinase-1%Neuroblastoma%Expression
目的 探讨鞘氨醇激酶1(SPHK1)在神经母细胞瘤中的表达及其临床意义.方法 通过免疫组织化学方法观察SPHK1在1995年1月至2009年10月我科连续收治的142例神经母细胞瘤石蜡切片的表达,分析其与神经母细胞瘤临床分期、预后等之间的关系.结果 142例神经母细胞瘤中SPHK1低表达69例,高表达73例.SPHK1的表达和神经母细胞瘤的INSS分期明显相关(P＜0.01),和生存亦明显相关(P＜0.01).结论 SPHK1在神经母细胞瘤中的表达和其临床分期及预后明显相关,可以作为神经母细胞瘤的肿瘤标记物.
目的 探討鞘氨醇激酶1(SPHK1)在神經母細胞瘤中的錶達及其臨床意義.方法 通過免疫組織化學方法觀察SPHK1在1995年1月至2009年10月我科連續收治的142例神經母細胞瘤石蠟切片的錶達,分析其與神經母細胞瘤臨床分期、預後等之間的關繫.結果 142例神經母細胞瘤中SPHK1低錶達69例,高錶達73例.SPHK1的錶達和神經母細胞瘤的INSS分期明顯相關(P＜0.01),和生存亦明顯相關(P＜0.01).結論 SPHK1在神經母細胞瘤中的錶達和其臨床分期及預後明顯相關,可以作為神經母細胞瘤的腫瘤標記物.
목적 탐토초안순격매1(SPHK1)재신경모세포류중적표체급기림상의의.방법 통과면역조직화학방법관찰SPHK1재1995년1월지2009년10월아과련속수치적142례신경모세포류석사절편적표체,분석기여신경모세포류림상분기、예후등지간적관계.결과 142례신경모세포류중SPHK1저표체69례,고표체73례.SPHK1적표체화신경모세포류적INSS분기명현상관(P＜0.01),화생존역명현상관(P＜0.01).결론 SPHK1재신경모세포류중적표체화기림상분기급예후명현상관,가이작위신경모세포류적종류표기물.
Objective To investigate the clinical significance of the expression of sphingolipids kinase-1 ( SPHK1 ) in neuroblastoma and its relationship with the clinical staging and prognosis of neuroblastoma. Methods The expression of SPHK1 in consecutive 142 paraffin-embedded sections of neuroblastoma from Jan. 1995 to Oct. 2009 was observed by immunohistological staining. The relationship between the expression of SPHK1 with the clinical staging and prognosis of neuroblastoma was analyzed. Results Low expression of SPHK1 was found in 69 cases of neuroblastoma and high expression in 73 cases. The expression of SPHK1 had a significant relationship with INSS staging (P ＜0.01 ) and survival (P ＜0.01 ) of patients with neuroblastoma. Conclusion There is a significant relationship between the expression of SPHK1 with the clinical staging and prognosis of neuroblastoma. SPHK1 can be used as a tumor marker of neuroblastoma.
