中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2009年
46期
3249-3252
,共4页
姜先洲%周长扩%郭丽华%陈静%王洪强%张东青%史本康%徐祗顺
薑先洲%週長擴%郭麗華%陳靜%王洪彊%張東青%史本康%徐祗順
강선주%주장확%곽려화%진정%왕홍강%장동청%사본강%서지순
早泄%感觉阈%球海绵体反射
早洩%感覺閾%毬海綿體反射
조설%감각역%구해면체반사
Premature ejaculation%Sensory thresholds%Bulbocavemosus reflex
目的 探讨前列腺部后尿道-球海绵体反射(BCR)在原发性早泄(PPE)发病机制中的作用.方法 对20名健康成年男性(健康对照组)及42例原发性早泄患者(原发性早泄组)应用-种特制尿道电极刺激前列腺部后尿道,通过诱发球海绵体反射,记录感觉阈值、诱发恒定反射阈值以及潜伏期.同时,采用表面电极,通过电刺激龟头,测定龟头生物感觉阈值.结果 健康对照组后尿道感觉阈值、诱发恒定反射阈值、反射潜伏期以及龟头生物感党阈值分别为(18.2±2.7)Ma(0.2 ms,1 Hz),(34.8±4.2)Ma(0.2 ms,1 Hz),(71.2±5.8)ms和(14.2±1.9)Ma(0.04 ms,3 Hz);原发性早泄组后尿道感觉阈值、诱发恒定反射阈值、反射潜伏期以及龟头生物感觉阈值分别为(12.4±3.7)Ma(0.2 ms,l Hz),(23.8±5.6)Ma(0.2 918,1 Hz),(70.5 4-6.3)ms和(11.9±2.3)Ma(0.04 ms,3Hz).原发性早泄组后尿道感觉阈值、诱发恒定反射阈值、以及龟头生物感觉阈值均低于健康对照组(均P<0.01).两组间反射潜伏期差异无统计学意义(P>0.05).结论 原发性早泄患者存在高兴奋性的前列腺部后尿道-球海绵体反射,这可能在原发性早泄的发病机制中具有重要的作用,同时也为探讨其他有效的治疗方法提供了新的途径.
目的 探討前列腺部後尿道-毬海綿體反射(BCR)在原髮性早洩(PPE)髮病機製中的作用.方法 對20名健康成年男性(健康對照組)及42例原髮性早洩患者(原髮性早洩組)應用-種特製尿道電極刺激前列腺部後尿道,通過誘髮毬海綿體反射,記錄感覺閾值、誘髮恆定反射閾值以及潛伏期.同時,採用錶麵電極,通過電刺激龜頭,測定龜頭生物感覺閾值.結果 健康對照組後尿道感覺閾值、誘髮恆定反射閾值、反射潛伏期以及龜頭生物感黨閾值分彆為(18.2±2.7)Ma(0.2 ms,1 Hz),(34.8±4.2)Ma(0.2 ms,1 Hz),(71.2±5.8)ms和(14.2±1.9)Ma(0.04 ms,3 Hz);原髮性早洩組後尿道感覺閾值、誘髮恆定反射閾值、反射潛伏期以及龜頭生物感覺閾值分彆為(12.4±3.7)Ma(0.2 ms,l Hz),(23.8±5.6)Ma(0.2 918,1 Hz),(70.5 4-6.3)ms和(11.9±2.3)Ma(0.04 ms,3Hz).原髮性早洩組後尿道感覺閾值、誘髮恆定反射閾值、以及龜頭生物感覺閾值均低于健康對照組(均P<0.01).兩組間反射潛伏期差異無統計學意義(P>0.05).結論 原髮性早洩患者存在高興奮性的前列腺部後尿道-毬海綿體反射,這可能在原髮性早洩的髮病機製中具有重要的作用,同時也為探討其他有效的治療方法提供瞭新的途徑.
목적 탐토전렬선부후뇨도-구해면체반사(BCR)재원발성조설(PPE)발병궤제중적작용.방법 대20명건강성년남성(건강대조조)급42례원발성조설환자(원발성조설조)응용-충특제뇨도전겁자격전렬선부후뇨도,통과유발구해면체반사,기록감각역치、유발항정반사역치이급잠복기.동시,채용표면전겁,통과전자격구두,측정구두생물감각역치.결과 건강대조조후뇨도감각역치、유발항정반사역치、반사잠복기이급구두생물감당역치분별위(18.2±2.7)Ma(0.2 ms,1 Hz),(34.8±4.2)Ma(0.2 ms,1 Hz),(71.2±5.8)ms화(14.2±1.9)Ma(0.04 ms,3 Hz);원발성조설조후뇨도감각역치、유발항정반사역치、반사잠복기이급구두생물감각역치분별위(12.4±3.7)Ma(0.2 ms,l Hz),(23.8±5.6)Ma(0.2 918,1 Hz),(70.5 4-6.3)ms화(11.9±2.3)Ma(0.04 ms,3Hz).원발성조설조후뇨도감각역치、유발항정반사역치、이급구두생물감각역치균저우건강대조조(균P<0.01).량조간반사잠복기차이무통계학의의(P>0.05).결론 원발성조설환자존재고흥강성적전렬선부후뇨도-구해면체반사,저가능재원발성조설적발병궤제중구유중요적작용,동시야위탐토기타유효적치료방법제공료신적도경.
objective Primary premature ejaculation (PPE) is a prevalent sexual dysfunction among men while its precise pathologic mechanism has remained poorly understood.In current study the correlation between excitability of bulbocavernosus reflex (BCR) to stimulation of prostatic urethra and primary premature ejaculation was studied.Methods Forty-two patients with PPE and 20 normal potent male volunteers were studied by inserting a specially designed Foley catheter with two electrodes mounted on its distal surface (intraurethral catheter electrode) into bladder to evoke the BCR to stimulation of prostatic urethra to record the sensory thresholds of BCR to stimulation of prostatic urethra.thresholds to evoke stable BCR and latencies of BCR Also the sensitivity of glans penis to electrical stimulation was detected by two surface electrodes.Resulis The mean sensory thresholds of BCR to stimulation of prostatic urethra. Thresholds to evoke stable BCR.latencies of BCR and sensory thresholds of glans penis were (18.2±2.7) Ma(0.2 ms in duration,1 Hz),(34.8±4.2)mA (0.2 ms,1 Hz),(71.2±5.8) ms and(14.2±1.9) mA(0.04 ms in duration.3 Hz) in normal potent men respectively and were (12.4±3.7)mA(0.2ms,1 Hz),(23.8 ±5.6)mA (0.2 ms,1 Hz),(70.5±6.3)ms and(11.9±2.3)mA(0.04 ms,3 Hz) in patients with PPE respectively.Statistically significant difierences were seen regarding the sensory thresholds of BCR to stimulation of prostatic urethra.the thresholds to evoke stable BCR and the sensory thresholds of glans penis between two groups(all P<0.01).No statistically differences were seen regarding the latencies of BCR between two groups (P>0.05).Conclusion Patients with PPE have hyperexcitable BCR to stimulation of prostatic urethrft It is probably one of the important etiological factors.Moreover the findings may provide new therapeutic modalities of PPE.
