兰州大学学报（医学版）
蘭州大學學報（醫學版）
란주대학학보（의학판）
JOURNAL OF LANZHOU UNIVERSITY(MEDICAL SCIENCES)
2009年
2期
58-59,63
,共3页
病毒性心肌炎%心肌肌钙蛋白Ⅰ%肌酸激酶同工酶-MB%儿童
病毒性心肌炎%心肌肌鈣蛋白Ⅰ%肌痠激酶同工酶-MB%兒童
병독성심기염%심기기개단백Ⅰ%기산격매동공매-MB%인동
viral myocarditis%cardiac troponin Ⅰ%creatine kinase-MB%child
目的 探讨血清心肌肌钙蛋白Ⅰ(cTnⅠ)及肌酸激酶同工酶-MB(CK-MB)对小儿病毒性心肌炎患者的诊断价值.方法 采用增强免疫比浊法及酶速率法测定59例病毒性心肌炎患儿、41例非心肌炎患儿和45例健康体检小儿的m清cTnⅠ及CK-MB阳性率.结果 3组间血清cTnⅠ比较和CK-MB比较,差异均有显著性(χ2=72.21,P<0.05;χ2=35.24,P<0.05);病毒性心肌炎组CK-MB阳性率较cTnⅠ阳性率低(χ2=4.32,P<0.05);非心肌炎组cTnⅠ阳性率低于CK-MB阳性率(χ2=21.09,P<0.05);对照组血清cTnⅠ和CK-MB阳性率均为0.血清CK-MB阳性率随病程延长下降,病程在1周内血清cTnⅠ阳性率高于血清CK-MB阳性率(χ2=4.50,P<0.05).结论 测定cTnⅠ对于诊断小儿病毒性心肌炎有较高的敏感性和特异性,可作为小儿病毒性心肌炎早期诊断的可靠指标.
目的 探討血清心肌肌鈣蛋白Ⅰ(cTnⅠ)及肌痠激酶同工酶-MB(CK-MB)對小兒病毒性心肌炎患者的診斷價值.方法 採用增彊免疫比濁法及酶速率法測定59例病毒性心肌炎患兒、41例非心肌炎患兒和45例健康體檢小兒的m清cTnⅠ及CK-MB暘性率.結果 3組間血清cTnⅠ比較和CK-MB比較,差異均有顯著性(χ2=72.21,P<0.05;χ2=35.24,P<0.05);病毒性心肌炎組CK-MB暘性率較cTnⅠ暘性率低(χ2=4.32,P<0.05);非心肌炎組cTnⅠ暘性率低于CK-MB暘性率(χ2=21.09,P<0.05);對照組血清cTnⅠ和CK-MB暘性率均為0.血清CK-MB暘性率隨病程延長下降,病程在1週內血清cTnⅠ暘性率高于血清CK-MB暘性率(χ2=4.50,P<0.05).結論 測定cTnⅠ對于診斷小兒病毒性心肌炎有較高的敏感性和特異性,可作為小兒病毒性心肌炎早期診斷的可靠指標.
목적 탐토혈청심기기개단백Ⅰ(cTnⅠ)급기산격매동공매-MB(CK-MB)대소인병독성심기염환자적진단개치.방법 채용증강면역비탁법급매속솔법측정59례병독성심기염환인、41례비심기염환인화45례건강체검소인적m청cTnⅠ급CK-MB양성솔.결과 3조간혈청cTnⅠ비교화CK-MB비교,차이균유현저성(χ2=72.21,P<0.05;χ2=35.24,P<0.05);병독성심기염조CK-MB양성솔교cTnⅠ양성솔저(χ2=4.32,P<0.05);비심기염조cTnⅠ양성솔저우CK-MB양성솔(χ2=21.09,P<0.05);대조조혈청cTnⅠ화CK-MB양성솔균위0.혈청CK-MB양성솔수병정연장하강,병정재1주내혈청cTnⅠ양성솔고우혈청CK-MB양성솔(χ2=4.50,P<0.05).결론 측정cTnⅠ대우진단소인병독성심기염유교고적민감성화특이성,가작위소인병독성심기염조기진단적가고지표.
Objective To study the clinical value of serum cardiac troponin Ⅰ (cTnⅠ) and creatine kinase-MB (CK-MB) in the diagnosis of children with viral myocarditis. Methods The methods of enhanced immune turbidimetry and enzyme rate were used to test the positive rate of cTnⅠ and CK-MB in the serum of 59 children with viral myocarditis,41 children without viral myocarditis and 41 healthy children. Results The contrast of the positive rate of cTnⅠ and CK-MB in the serum among the three groups showed the significant differences (χ2=72.21,P <0.05; χ2=35.24, P<0.05). The positive rate of CK-MB was lower than that of cTnⅠ in children with viral myocarditis (χ2=4.32,P <0.05). The positive rate of cTnI was lower than that of CK-MB in children without viral myocarditis (χ2= 21.09,P <0.05). The positive rate of cTnⅠ and CK-MB in the serum of healthy children was the same 0. The positive rate of CK-MB in serum was decreasing along with the prolonged course of disease. When the course of disease was within one week,the positive rate of cTnI in serum was higher than that of CK-MB (χ2=4.50,P<0.05). Conclusion The cTnⅠ in serum has high sensitivity and specificity to diagnose children with viral myocarditis. Thus it can be used as the reliable indicator for the early diagnosis of the children patients with viral myocarditis.
