CAJ | 학술논문

目的:探讨非酒精性脂肪肝患者胰岛β细胞的功能和胰岛素抵抗的特征.方法:研究对象收集于青岛大学医学院附属医院和即墨市人民医院,共60例,分为非酒精性脂肪肝组30例,正常对照组30例,对两组体重指数、糖化血红蛋白、胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、血糖、胰岛素水平进行比较,同时采用胰岛素抵抗指数(HOMA-IR)评估胰岛素抵抗性,胰岛素曲线下面积反映胰岛β细胞在葡萄糖刺激下总体分泌胰岛素情况,早相胰岛素分泌指数(△I30/△G30)、胰岛β细胞功能(HOMA-β)评估早时相和晚时相胰岛素分泌功能,并对各指标和影响因素之间进行相关性分析.结果:非酒精性脂肪肝病(NAFLD)组的BMI、TC、TG、HDL-c、LDL-c、HbA1c、0min、30min、120min血糖均高于对照组(t=4.877,3.677,2.388,3.589,2.616,2.21,3.850,2.254,3.913,P=0.001,0.001,0.020,0.002,0.031,0.001,0.014,0.001,0.02),NAFLD组HOMA-IR高于对照组(t=4.482,P=0.001),两组间的早相分泌和晚相分泌、曲线下面积无差异(P>0.05).HbA1c、TC、0 min、60min、120min血糖与胰岛素抵抗相关(R=0.542、R=0.675、R=0.832、R=0.499、R=0.974,P<0.05);HDL-c、0 min血糖、0 min胰岛素与早时相分泌相关(R=-0.556、R=0.519、R=0.529,P<0.05);0 min血糖、0min胰岛素与晚时相相关(R=-0.771、R=0.767,P<0.05).结论:非酒精性脂肪肝组存在胰岛素抵抗,胰岛β细胞功能在早期尚未受损.
목적:탐토비주정성지방간환자이도β세포적공능화이도소저항적특정.방법:연구대상수집우청도대학의학원부속의원화즉묵시인민의원,공60례,분위비주정성지방간조30례,정상대조조30례,대량조체중지수、당화혈홍단백、담고순、감유삼지、고밀도지단백、저밀도지단백、혈당、이도소수평진행비교,동시채용이도소저항지수(HOMA-IR)평고이도소저항성,이도소곡선하면적반영이도β세포재포도당자격하총체분비이도소정황,조상이도소분비지수(△I30/△G30)、이도β세포공능(HOMA-β)평고조시상화만시상이도소분비공능,병대각지표화영향인소지간진행상관성분석.결과:비주정성지방간병(NAFLD)조적BMI、TC、TG、HDL-c、LDL-c、HbA1c、0min、30min、120min혈당균고우대조조(t=4.877,3.677,2.388,3.589,2.616,2.21,3.850,2.254,3.913,P=0.001,0.001,0.020,0.002,0.031,0.001,0.014,0.001,0.02),NAFLD조HOMA-IR고우대조조(t=4.482,P=0.001),량조간적조상분비화만상분비、곡선하면적무차이(P>0.05).HbA1c、TC、0 min、60min、120min혈당여이도소저항상관(R=0.542、R=0.675、R=0.832、R=0.499、R=0.974,P<0.05);HDL-c、0 min혈당、0 min이도소여조시상분비상관(R=-0.556、R=0.519、R=0.529,P<0.05);0 min혈당、0min이도소여만시상상관(R=-0.771、R=0.767,P<0.05).결론:비주정성지방간조존재이도소저항,이도β세포공능재조기상미수손.