国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
INTERNATIONAL JOURNAL OF PEDIATRICS
2012年
5期
503-506
,共4页
胰岛素样生长因子结合蛋白7%肿瘤%信号传导通路
胰島素樣生長因子結閤蛋白7%腫瘤%信號傳導通路
이도소양생장인자결합단백7%종류%신호전도통로
Insulin-like growth factor binding protein 7%Tumor%Signal transduction pathway
胰岛素样生长因子结合蛋白7(insulin-like growth factor binding protein 7,IGFBP7)通过与胰岛素样生长因子(insulin-like growth factor,IGF)、胰岛素相结合,延长IGF/胰岛素的半衰期,从而发挥IGF/胰岛素的生物学功能.与其他结合蛋白不同的是,IGFBP7能与胰岛素强有力的结合,从而能够不依赖IGF而发挥功能.IGFBP7在细胞生长、增殖和在肿瘤细胞的黏附、浸润、迁徙及肿瘤血管的形成等方面发挥作用,可能与某种信号传导通路有关.
胰島素樣生長因子結閤蛋白7(insulin-like growth factor binding protein 7,IGFBP7)通過與胰島素樣生長因子(insulin-like growth factor,IGF)、胰島素相結閤,延長IGF/胰島素的半衰期,從而髮揮IGF/胰島素的生物學功能.與其他結閤蛋白不同的是,IGFBP7能與胰島素彊有力的結閤,從而能夠不依賴IGF而髮揮功能.IGFBP7在細胞生長、增殖和在腫瘤細胞的黏附、浸潤、遷徙及腫瘤血管的形成等方麵髮揮作用,可能與某種信號傳導通路有關.
이도소양생장인자결합단백7(insulin-like growth factor binding protein 7,IGFBP7)통과여이도소양생장인자(insulin-like growth factor,IGF)、이도소상결합,연장IGF/이도소적반쇠기,종이발휘IGF/이도소적생물학공능.여기타결합단백불동적시,IGFBP7능여이도소강유력적결합,종이능구불의뢰IGF이발휘공능.IGFBP7재세포생장、증식화재종류세포적점부、침윤、천사급종류혈관적형성등방면발휘작용,가능여모충신호전도통로유관.
Insulin-like growth factor binding protein 7 exert modulatory function in insulin-like growth factor/insulin(IGF/INS) protein network by carrying and transiting IGF/INS,or prolonging their half-life.IGFBP7 has strong ability to bind insulin and low affinity to IGFs and plays a role in either IGFs-dependent way or IGFs-independent way.IGFBP7 involves in multiple function such as cell proliferation,adhesion,invasion,migration and tumor vascular formation through several signaling pathways.
