CAJ | 학술논문

随着食管癌发生、发展过程中分子生物学机制研究的不断深入,与食管癌化疗相关的基因、蛋白,如表皮生长因子受体(EGFR)、抑癌基因p53、剪切修复耦联因子1(ERCC1)、多药耐药相关蛋白(MRP)、P-糖蛋白(P-gp)等的研究取得了较大进展.检测这些基因和蛋白将有利于预测食管癌化疗敏感性并制定合理的个体化治疗方案.
수착식관암발생、발전과정중분자생물학궤제연구적불단심입,여식관암화료상관적기인、단백,여표피생장인자수체(EGFR)、억암기인p53、전절수복우련인자1(ERCC1)、다약내약상관단백(MRP)、P-당단백(P-gp)등적연구취득료교대진전.검측저사기인화단백장유리우예측식관암화료민감성병제정합리적개체화치료방안.
With the deep study of the molecular biology mechanism during esophageal carcinoma development, there are major progressions in the study of chemotherapy related genes and proteins in esophageal carcinoma, including EGFR, p53, ERCC1, MRP and P-gp, and the measurements of these genes and protein benefit the prediction of chemotherapy sensitivity and making the individualized treatment protocols.