国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2007年
11期
862-866
,共5页
吴福国%陈一戎%王学春%CHENG Li
吳福國%陳一戎%王學春%CHENG Li
오복국%진일융%왕학춘%CHENG Li
RNA interference%RNA,small interfering%MicroRNAs%Neoplasms
RNA interference(RNAi), a highly conserved process of post-transcriptional gene silencing, can be induced by small interfering double-stranded RNA that mediate sequence-specific mRNA degradation. In the past several years, RNAi has been widely used as both an experimental tool to study mammalian gene function and a potential therapeutic approach to treat human diseases. In addition, some new proteins which involve in RNAi pathway have been characterized in mammalian cells. Here, we summarize the various molecules in RNAi, mechanism of action, and the current therapeutic applications in cancers.
