中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2009年
5期
455-458
,共4页
丁建华%李苏平%曹海霞%吴建中%高长明%苏平%刘燕婷%周建农%常军%姚根红
丁建華%李囌平%曹海霞%吳建中%高長明%囌平%劉燕婷%週建農%常軍%姚根紅
정건화%리소평%조해하%오건중%고장명%소평%류연정%주건농%상군%요근홍
食道肿瘤%乙醇脱氢酶2%乙醛脱氢酶2%基因多态性%病例对照研究
食道腫瘤%乙醇脫氫酶2%乙醛脫氫酶2%基因多態性%病例對照研究
식도종류%을순탈경매2%을철탈경매2%기인다태성%병례대조연구
Esophageal neoplasms%Alcohol dehydrogenase-2%Aldehyde dehydrogenase-2%Genetic polymorphisms%Case-control study
目的 研究乙醇脱氢酶2(ADH2)和乙醛脱氧酶2(ALDH2)基因多态与食道癌易感性.方法 对江苏省泰兴市221例食道癌新发病例和191名对照的饮酒习惯等因素进行调查,采用PCR和变性高效液相色谱法(DHPLC)检测ADH2和ALDH2基因型.结果 (1)与携带ALDH2 G/G基因型者相比,携带ALDH2A/A(OR=5.69,95%CI:2.51～12.18)和ALDH2 G/A(OR=1.70,95%CI:1.08～2.68)基因型者患食道癌危险性明显增加,以携带ALDH2A/A的饮酒者最为显著(OR=8.63,95%CI:2.07～35.95).(2)无论是否饮酒,携带不同ADH2基因型者之间患食道癌的风险差异均无统计学意义.(3)携带ALDH2 A/A或G/A基因型者,不论同时携带何种ADH2基因型患食道癌的风险均显著增加,且作用效应为ALDH2 A/A≥G/A.(4)与同时携带ALDH2 G/G和ADH2 A/A的不饮酒者相比,同时携带ALDH2 G/A或A/A和ADH2 G/A或G/G的饮酒者,患食道癌危险性OR值高达8.36(95%CI:2.98～23.46).结论 饮酒及醇醛脱氢酶基因多态与食道癌的联系主要与ALDH2有关;携带ALDH2A/A和G/A者减少酒精消耗量,有助于降低患食道癌危险性.
目的 研究乙醇脫氫酶2(ADH2)和乙醛脫氧酶2(ALDH2)基因多態與食道癌易感性.方法 對江囌省泰興市221例食道癌新髮病例和191名對照的飲酒習慣等因素進行調查,採用PCR和變性高效液相色譜法(DHPLC)檢測ADH2和ALDH2基因型.結果 (1)與攜帶ALDH2 G/G基因型者相比,攜帶ALDH2A/A(OR=5.69,95%CI:2.51～12.18)和ALDH2 G/A(OR=1.70,95%CI:1.08～2.68)基因型者患食道癌危險性明顯增加,以攜帶ALDH2A/A的飲酒者最為顯著(OR=8.63,95%CI:2.07～35.95).(2)無論是否飲酒,攜帶不同ADH2基因型者之間患食道癌的風險差異均無統計學意義.(3)攜帶ALDH2 A/A或G/A基因型者,不論同時攜帶何種ADH2基因型患食道癌的風險均顯著增加,且作用效應為ALDH2 A/A≥G/A.(4)與同時攜帶ALDH2 G/G和ADH2 A/A的不飲酒者相比,同時攜帶ALDH2 G/A或A/A和ADH2 G/A或G/G的飲酒者,患食道癌危險性OR值高達8.36(95%CI:2.98～23.46).結論 飲酒及醇醛脫氫酶基因多態與食道癌的聯繫主要與ALDH2有關;攜帶ALDH2A/A和G/A者減少酒精消耗量,有助于降低患食道癌危險性.
목적 연구을순탈경매2(ADH2)화을철탈양매2(ALDH2)기인다태여식도암역감성.방법 대강소성태흥시221례식도암신발병례화191명대조적음주습관등인소진행조사,채용PCR화변성고효액상색보법(DHPLC)검측ADH2화ALDH2기인형.결과 (1)여휴대ALDH2 G/G기인형자상비,휴대ALDH2A/A(OR=5.69,95%CI:2.51～12.18)화ALDH2 G/A(OR=1.70,95%CI:1.08～2.68)기인형자환식도암위험성명현증가,이휴대ALDH2A/A적음주자최위현저(OR=8.63,95%CI:2.07～35.95).(2)무론시부음주,휴대불동ADH2기인형자지간환식도암적풍험차이균무통계학의의.(3)휴대ALDH2 A/A혹G/A기인형자,불론동시휴대하충ADH2기인형환식도암적풍험균현저증가,차작용효응위ALDH2 A/A≥G/A.(4)여동시휴대ALDH2 G/G화ADH2 A/A적불음주자상비,동시휴대ALDH2 G/A혹A/A화ADH2 G/A혹G/G적음주자,환식도암위험성OR치고체8.36(95%CI:2.98～23.46).결론 음주급순철탈경매기인다태여식도암적련계주요여ALDH2유관;휴대ALDH2A/A화G/A자감소주정소모량,유조우강저환식도암위험성.
Objective To evaluate the impact of alcohol dehydrogenase-2 (ADH2) and aldehyde dehydrogenase-2 (ALDH2) polymorphisms on the susceptibility of esophageal cancer. Methods A case-control study including 221 cases of esophageal cancer and 191 controls was carried out in Taixing city of Jiangsu province. ADH2 and ALDH2 genotypes were tested by PCR and denaturing high -- performance liquid chromatography (DHPLC). Results (1) Compared with ALDH2 G/G carriers, ALDH2 A/A (OR=5.69, 95%CI: 2.51-12.18) and ALDH2 G/A (OR=1.70, 95%CI: 1.08-2.68) carriers showed a significantly elevated risk of developing esophageal cancer, especially among alcohol drinkers with ALDH2 A/A (OR=8.63,95% CI: 2.07-35.95). (2) Statistical relation was not found between ADH2 genotypes and the risk of esophageal cancer, with regard to the status of alcohol consumption. (3) Whether subjects with whatever ADH2 genotype, ALDH2 G/A or A/A carriers was found to have significantly increased the risk of developing esophageal cancer, with ALDH2 A/A carriers appeared having higher esophageal cancer risk than those ALDH2 G/A carriers. (4)Compared those non-drinkers with both ALDH2 G/G and ADH2 A/A , drinkers with ALDH2 G/A or A/A and ADH2 C,/A or G/G genotypes showed a significantly elevated risk of developing esophageal cancer (OR=8.36, 95% CI: 2.98-23.46). Conclusion These results revealed that it was not ADH2 but ALDH2 polymorphisms and drinking alcohol had a significant interaction with the development of esophageal cancer, suggesting that in order to help lowering the risk of esophageal cancer, individuals who are carrying ALDH2 A/A or G/A genotypes should be encouraged to reduce their consumption of alcohols.
