CAJ | 학술논문

目的研究植入型长效纳曲酮缓释剂(Long-term sustained release naltrexone,LSRNTX)对海洛因依赖者心理渴求的疗效.方法对接受植入型LSRNTX治疗的108例海洛因依赖患者,进行治疗前后的海洛因渴求量表分析,同步进行治疗后尿液吗啡、美沙酮和丁丙诺啡突击性定性检测.结果 (1)108例患者接受植入型LSRNTX治疗后海洛因渴求量表总分及用药意向、用药渴望、效果期待、自我控制4个因子得分均显著低于治疗前得分,差异具有统计学意义.(2)治疗后的108例患者中,95例(87.96%)尿吗啡、美沙酮、丁丙诺啡检测结果为全阴性,阳性结果者13例(12.04%).(3)治疗后尿液检测阴性结果者海洛因渴求量表得分较治疗前得分减低幅度高于阳性结果者得分减低幅度.结论植入型LSRNTX对海洛因依赖患者具有降低心理渴求的良好疗效,有利于防治海洛因依赖患者复吸.
목적 연구식입형장효납곡동완석제(Long-term sustained release naltrexone,LSRNTX)대해락인의뢰자심리갈구적료효.방법 대접수식입형LSRNTX치료적108례해락인의뢰환자,진행치료전후적해락인갈구량표분석,동보진행치료후뇨액마배、미사동화정병낙배돌격성정성검측.결과 (1)108례환자접수식입형LSRNTX치료후해락인갈구량표총분급용약의향、용약갈망、효과기대、자아공제4개인자득분균현저저우치료전득분,차이구유통계학의의.(2)치료후적108례환자중,95례(87.96%)뇨마배、미사동、정병낙배검측결과위전음성,양성결과자13례(12.04%).(3)치료후뇨액검측음성결과자해락인갈구량표득분교치료전득분감저폭도고우양성결과자득분감저폭도.결론 식입형LSRNTX대해락인의뢰환자구유강저심리갈구적량호료효,유리우방치해락인의뢰환자복흡.
Objective To investigate heroin craving changes among heroin dependence treated with longterm sustained release naltrexone(LSRNTX)implants.Methods Before and after the treatment of LSRNTX implants,the levels of heroin craving were evaluated with Rating Scale for Heroin Craving among 108 heroin addicts,and urine analysis for morphine,methadone,and buprenorphine were performed among them without prior notification.Results(1)After the treatment of LSRNTX implants,the total scores of Rating Scale for Heroin Craving and the scores of the four factors of abusing intent,abusing spiration,expect effect,and self-control among the 108 heroin addicts were much less lower than those before the treatment,and the differences are statistically significant.(2)After the treatment,the outcomes of urine analysis for morphine,methadone,and buprenorphine were completely negative among 95 subjects(87.96%),the positive outcomes were found in 13(12.04%)subjects.(3)After the treatment,the scores of Rating Scale for Heroin Craving among the subjects with negative outcome of urine analysis decreased much more significantly than those of the subjects with positive outcome.Conclusion The LSRNTX implants are effective on palliating or eliminating heroin craving,and help to prevent the heroin addicts from relapsing.