CAJ | 학술논문

目的探讨血清唾液酸(SA)在恶性肿瘤中的临床应用价值.方法采用酶法对50名健康人、90例良性疾病及160例恶性肿瘤患者血清SA的水平进行检测,分析血清SA水平在肿瘤不同病理类型及相关治疗前后的表达变化.结果恶性肿瘤各组血清SA水平均显著高于良性疾病组及健康对照组(P<0.01),恶性肿瘤各组阳性率亦显著高于良性疾病组(P<0.01);各组织学类型恶性肿瘤组血清SA水平显著高于良性疾病组及健康对照组(P<0.01),但各组织学类型恶性肿瘤组之间血清SA水平差异无统计学意义(P>0.05);恶性肿瘤患者经相关治疗后,病情好转组血清SA水平明显下降,与治疗前相比差异有统计学意义(P<0.01);病情恶化组血清SA水平有上升趋势,但与治疗前相比差异无统计学意义(P>0.05).结论血清SA对恶性肿瘤的诊断、治疗、疗效判断、病情监测及预后判断具有一定临床应用价值.
목적 탐토혈청타액산(SA)재악성종류중적림상응용개치.방법 채용매법대50명건강인、90례량성질병급160례악성종류환자혈청SA적수평진행검측,분석혈청SA수평재종류불동병리류형급상관치료전후적표체변화.결과 악성종류각조혈청SA수평균현저고우량성질병조급건강대조조(P<0.01),악성종류각조양성솔역현저고우량성질병조(P<0.01);각조직학류형악성종류조혈청SA수평현저고우량성질병조급건강대조조(P<0.01),단각조직학류형악성종류조지간혈청SA수평차이무통계학의의(P>0.05);악성종류환자경상관치료후,병정호전조혈청SA수평명현하강,여치료전상비차이유통계학의의(P<0.01);병정악화조혈청SA수평유상승추세,단여치료전상비차이무통계학의의(P>0.05).결론 혈청SA대악성종류적진단、치료、료효판단、병정감측급예후판단구유일정림상응용개치.
Objective To study the diagnosis value and clinical significance of serum sialic acid in malignant tumor. Methods Using enzymic method, the serum sialic acid levels were detected in 50 healthy persons, 90 benign disease patients, 160 malignant tumor patients. The serum sialic acid levels change were analyzed in different pathological types and after relative treatment. Results The serum sialic acid levels and positive ratio in malignant tumor groups were apparently higher than those in normal control and benign disease groups (P<0.01). The serum sialic acid levels in malignant tumor of different pathological types were apparently higher than those in normal control and benign disease groups (P <0.01), while there was no significance between different pathological types (P >0.05). The serum sialic acid levels in the improved patients significantly dropped (P <0.01), while those in the aggravated patients had an ascendent tendency.Conclusion The serum sialic acid has significant value in diagnosis, therapeutic effect and prognosis of malignant tumor.