CAJ | 학술논문

目的：探讨婴幼儿重症肺炎伴发肾功能损害时血清β2-微球蛋白(β2-MG)与肌酐(Cr)、尿素氮(BUN)测定的诊断意义。方法：观察组为PICU抢救治疗的68例婴幼儿重症肺炎于入院24h内及病情缓解后分别测定血清β2-MG及BUN、Cr，设22例正常儿童为对照组。结果：血清β2-MG第1次测定与对照组比较有极显著性差异(t=13．256，P<0.001)，第2次测定无显著性差异(t=0．6963，P>0.05)。2次BUN、Cr测定均在正常范围，与对照组比较无显著性差异。结论：婴幼儿重症肺炎时，肾功能损害普遍存在，血清β2-MG测定能早期及时发现肾功能改变。
목적：탐토영유인중증폐염반발신공능손해시혈청β2-미구단백(β2-MG)여기항(Cr)、뇨소담(BUN)측정적진단의의。방법：관찰조위PICU창구치료적68례영유인중증폐염우입원24h내급병정완해후분별측정혈청β2-MG급BUN、Cr，설22례정상인동위대조조。결과：혈청β2-MG제1차측정여대조조비교유겁현저성차이(t=13．256，P<0.001)，제2차측정무현저성차이(t=0．6963，P>0.05)。2차BUN、Cr측정균재정상범위，여대조조비교무현저성차이。결론：영유인중증폐염시，신공능손해보편존재，혈청β2-MG측정능조기급시발현신공능개변。
Objective:To evaluate the significance of determinations of serum β2-microglobulin(β2-MG),serum creatinine(Cr) and blood urea nitrogen (BUN) in prediction of renal condition impaired associated with severe pneumonia in the infants.Methods:Sixty-eight infants with severe pneumonia admitted into the pediatric intensive care unit(PICU) were selected for the trial group,the serum levels of β2-MG,BUN and Cr were determined in 24 hours after admission and at the time when the disease was relieved.Other 22 healthy infants served the control group.The results were presented as ±s and the significance of difference was evaluated by t test.Results:The serum β2-MG concentration of the ill infant measured at 24h after admission was 3.474±0.27mg*L-1,significanlly higher than that of the control group (2.387±0.21mg*L-1),no significant difference was observed between serum β2-MG levels of the trial group determined when disease was relieved and that measured in the control infants.All measurements of BUN and Cr were within normal range(2.387±0.27mg*L-1) and no significant difference was seen as compared to the control.Conclusions:It is found that renal function impairment is commonly associated with severe pneumonia in infants,and determination of serum β2-MG can be used to predict renal function conditions.