广州地区新型甲型H1N1流感患者病毒RNA检出率与病程关系的研究
엄주지구신형갑형H1N1류감환자병독RNA검출솔여병정관계적연구
Relation between clinical detection rates of the novel influenza virus A/ H1N1 RNA in confirmed patients in Guangzhou and the disease course
  • 万方数据
    南方医科大学学报 남방의과대학학보
    JOURNAL OF SOUTHERN MEDICAL UNIVERSITY
    2009年 11期 2313-2315 ,共3页

    白志军%吴新伟%伍业建%李美霞%许杨%谢华萍%陈艺韵%蒋力云%刘于飞%李铁钢%杨智聪%王呜%狄飚

    백지군%오신위%오업건%리미하%허양%사화평%진예운%장력운%류우비%리철강%양지총%왕오%적표

    甲型H1N1流感病毒%病程%人群年龄分布%荧光定量RT-PCR 甲型H1N1流感病毒%病程%人群年齡分佈%熒光定量RT-PCR
    갑형H1N1류감병독%병정%인군년령분포%형광정량RT-PCR
    H1N1 subtype influenza A virus%disease course%age distribution%real-time polymerase chain reaction
    目的 探讨2009年新型甲型H1N1流感患者病毒RNA检出率与人群年龄分布和病程变化的关系.方法 选取广州地区新型甲型H1N1临床病例共248例,对151例进行病程动态咽拭子采样833份,统计分析患病人群年龄分布和采用荧光定量RT-PCR方法对不同病程的患者咽拭子标本进行甲型HINl流感病毒RNA的检测,并采用趋势x~2检验探讨标本阳性率与不同发病时间的关系.结果 发病人群以青壮年为主,主要集中在10～20岁(57.26%)和20～30岁(22.18%)两个年龄段.对咽拭子标本阳性率随发病时间的变化进行趋势x~2结果显示标本阳性率随着病程的延长而下降(x~2=9.784,P=0.002).讨论此次研究表明新型H1N1流感患者主要集中在青壮年人群中,且有最长可达10天以上的病程,标本阳性率随着病程的延长而下降.
    목적 탐토2009년신형갑형H1N1류감환자병독RNA검출솔여인군년령분포화병정변화적관계.방법 선취엄주지구신형갑형H1N1림상병례공248례,대151례진행병정동태인식자채양833빈,통계분석환병인군년령분포화채용형광정량RT-PCR방법대불동병정적환자인식자표본진행갑형HINl류감병독RNA적검측,병채용추세x~2검험탐토표본양성솔여불동발병시간적관계.결과 발병인군이청장년위주,주요집중재10～20세(57.26%)화20～30세(22.18%)량개년령단.대인식자표본양성솔수발병시간적변화진행추세x~2결과현시표본양성솔수착병정적연장이하강(x~2=9.784,P=0.002).토론차차연구표명신형H1N1류감환자주요집중재청장년인군중,차유최장가체10천이상적병정,표본양성솔수착병정적연장이하강.
    Objective To study the relation of the detection rates of the novel influenza virus A/H1N1 RNA in clinically confirmed patients in the 2009 pandemic with the age distribution of the patients and the disease course. Methods A total of 151 clinical patients with H1N1 infection were enrolled in this study, from whom 833 dynamic throat swab samples were obtained for detecting the H1N1 RNA using real-time PCR. A statistical analysis of the age distribution was performed among the patients with different disease courses. Chi-square for trend test was used to study the correlation between the detection rates of H1N1 RNA and the time of disease onset. Results The majority of patients were young with their ages ranging from 10 to 20 years (57.26%) and 20 to 30 years (22.18%). Chi-square for trend test revealed that the positivity rates of the throat swabs in the patients decreased with the prolongation of the disease course (x~2=9.784, P=0.002). Conclusion Most of the H1N1 patients are young within the age range of 10-30 years, and the longest disease course can exceed 10 days. The positivity rates of throat swabs from the H1N1 patients decreases with the prolongation of the disease course.
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