中国全科医学
中國全科醫學
중국전과의학
CHINESE GENERAL PRACTICE
2010年
7期
735-737
,共3页
李侗曾%田亚昆%李在村%吴昊
李侗曾%田亞昆%李在村%吳昊
리동증%전아곤%리재촌%오호
肺孢子菌肺炎%获得性免疫缺陷综合征%血气分析%低氧血症
肺孢子菌肺炎%穫得性免疫缺陷綜閤徵%血氣分析%低氧血癥
폐포자균폐염%획득성면역결함종합정%혈기분석%저양혈증
Pneumocystis jirovecii pneumonia%Acquired immunodeficiensy syndrome%Blood gas anaylysis%Hypoxemia
目的 探讨AIDS合并肺孢子菌肺炎(PCP)患者临床特点及其与预后相关的因素.方法 采用回顾性研究方法分析我院88例AIDS合并PCP患者的一般资料、感染途径、血气分析、血常规、血清清蛋白、血乳酸脱氢酶、治疗和转归情况等临床资料.按照PaO_2水平将88例AIDS患者分为轻度异常组(PaO_2＞70 mm Hg),中度异常组(50 mm Hg≤PaO_2≤70 mm Hg)和重度异常组(PaO_2＜50 mm Hg)3组,比较3组的一般资料和实验室检查结果,分析影响预后的因素.结果 3组患者的血清清蛋白水平、死亡率比较差异有统计学意义(P＜0.05).存活患者与死亡患者两组比较,PaO_2和SaO_2下降以及是否需要呼吸机呼吸支持两组间差异有统计学意义(P＜0.05).结论 PaO_2、血清清蛋白水平下降是发现AIDS合并PCP患者病情加重和预后不良的指标,治疗中应予重视并尽早给氧和营养支持治疗.
目的 探討AIDS閤併肺孢子菌肺炎(PCP)患者臨床特點及其與預後相關的因素.方法 採用迴顧性研究方法分析我院88例AIDS閤併PCP患者的一般資料、感染途徑、血氣分析、血常規、血清清蛋白、血乳痠脫氫酶、治療和轉歸情況等臨床資料.按照PaO_2水平將88例AIDS患者分為輕度異常組(PaO_2＞70 mm Hg),中度異常組(50 mm Hg≤PaO_2≤70 mm Hg)和重度異常組(PaO_2＜50 mm Hg)3組,比較3組的一般資料和實驗室檢查結果,分析影響預後的因素.結果 3組患者的血清清蛋白水平、死亡率比較差異有統計學意義(P＜0.05).存活患者與死亡患者兩組比較,PaO_2和SaO_2下降以及是否需要呼吸機呼吸支持兩組間差異有統計學意義(P＜0.05).結論 PaO_2、血清清蛋白水平下降是髮現AIDS閤併PCP患者病情加重和預後不良的指標,治療中應予重視併儘早給氧和營養支持治療.
목적 탐토AIDS합병폐포자균폐염(PCP)환자림상특점급기여예후상관적인소.방법 채용회고성연구방법분석아원88례AIDS합병PCP환자적일반자료、감염도경、혈기분석、혈상규、혈청청단백、혈유산탈경매、치료화전귀정황등림상자료.안조PaO_2수평장88례AIDS환자분위경도이상조(PaO_2＞70 mm Hg),중도이상조(50 mm Hg≤PaO_2≤70 mm Hg)화중도이상조(PaO_2＜50 mm Hg)3조,비교3조적일반자료화실험실검사결과,분석영향예후적인소.결과 3조환자적혈청청단백수평、사망솔비교차이유통계학의의(P＜0.05).존활환자여사망환자량조비교,PaO_2화SaO_2하강이급시부수요호흡궤호흡지지량조간차이유통계학의의(P＜0.05).결론 PaO_2、혈청청단백수평하강시발현AIDS합병PCP환자병정가중화예후불량적지표,치료중응여중시병진조급양화영양지지치료.
Objective To investigate the clinical characteristics and correlative factors with prognosis in AIDS patients complicated by Pneumocystis jirovecii pneumonia (PCP).Methods The data of 88 adults AIDS patients with PCP were retrospectively analyzed,including general data,and such clinical data as routes of HIV infection,blood gas analysis,blood routine,serum albumin,serum lactate dehydrogenase,therapeutic managements and clinical outcomes.The patients were divided according to the levels of their PaO_2 as mild group (PaO_2＞70 mm Hg),moderate group (50 mm Hg≤PaO_2≤70 mm Hg) and severe group (PaO_2＜50 mm Hg).The data of the patients in the 3 groups were compared and the prognosis influencing factors were also analyzed.Results There were significant difference among the three groups in serum albumin level and mortality rate (P＜0.05).There were also significant differences between the died and the survived in decreases of PaO_2 and SaO_2,and need of mechanical ventilation (P＜0.05).Conclusion Blood gas analysis and decrease of serum albumin level are the indexes to determine the deterioration and unfavorable prognosis of AIDS patients complicated by PCP,which needs to be paid attention to,and oxygen and nutrition therapy should be given as soon as possible.
