CAJ | 학술논문

受体酪氨酸激酶c-Met是由原癌基因c-Met所编码的,具有控制细胞生长、侵袭和抗凋亡等生物学作用.c-Met的异常表达与肺癌的发生、发展及恶性生物学行为关系密切.针对c-Met通路的靶向治疗是目前肺癌治疗的新热点.本文将就受体酪氨酸激酶c-Met的生物学特征、与肺癌的关系及其在肺癌治疗中的应用作一综述.
수체락안산격매c-Met시유원암기인c-Met소편마적,구유공제세포생장、침습화항조망등생물학작용.c-Met적이상표체여폐암적발생、발전급악성생물학행위관계밀절.침대c-Met통로적파향치료시목전폐암치료적신열점.본문장취수체락안산격매c-Met적생물학특정、여폐암적관계급기재폐암치료중적응용작일종술.
Receptor tyrosine kinase c-Met is encoded by c-Met proto-oncogene. It plays an important role in cell growth,invasion,anti-apoptosis,and other biological effects. The abnormal expression of c-Met is closely related with the development and malignant biological behaviour of lung cancer. The targeted therapy for c-Met pathway is the new hot spot of lung cancer treatment. This paper reviews biological characteristics of receptor tyrosine kinase c-Met,its relationship with lung cancer,and the application in treatment of lung cancer.