CAJ | 학술논문

目的了解精神分裂症患者的运动阈值(MT)与正常人的差异,以探讨精神分裂症患者的皮层兴奋性变化.方法采用单脉冲经颅磁刺激(sTMS)检测均为右利手的48例精神分裂症患者和48例正常对照的MT值.结果精神分裂症患者的MT值为左侧(47.01±9.14)高于右侧(44.59±10.54),差异有显著性(P＜0.05);而正常对照的MT值为左侧(41.79±7.65)低于右侧(44.63±7.96),差异有非常显著性(P＜0.01);精神分裂症患者左侧的MT值显著高于正常对照(P＜0.05),而右侧的MT值与正常对照差异无显著性(P＞0.05).结论精神分裂症患者的皮层兴奋性与正常对照存在差异,具体表现为患者左、右两侧皮层兴奋性的不对称性与正常对照呈相反表现;精神分裂症患者左侧大脑皮层的兴奋性明显降低.
목적 료해정신분렬증환자적운동역치(MT)여정상인적차이,이탐토정신분렬증환자적피층흥강성변화.방법 채용단맥충경로자자격(sTMS)검측균위우리수적48례정신분렬증환자화48례정상대조적MT치.결과 정신분렬증환자적MT치위좌측(47.01±9.14)고우우측(44.59±10.54),차이유현저성(P＜0.05);이정상대조적MT치위좌측(41.79±7.65)저우우측(44.63±7.96),차이유비상현저성(P＜0.01);정신분렬증환자좌측적MT치현저고우정상대조(P＜0.05),이우측적MT치여정상대조차이무현저성(P＞0.05).결론 정신분렬증환자적피층흥강성여정상대조존재차이,구체표현위환자좌、우량측피층흥강성적불대칭성여정상대조정상반표현;정신분렬증환자좌측대뇌피층적흥강성명현강저.
Objective To investigate the difference of motor threshold(MT)between the schizophrenic patients and normal volunteers.and analyze the change of cortical excitability in patients.Methods 48 righthanded patients with schizophrenia and 48 right-handed healthy control subjects were used signal-pulse Transcranial Magnetic Stimulation(sTMS)to detect the MT.Resuits MT in left(47.01±9.14)was higher than right (44.59±10.54)in patients,and reverse in normal controls(t1=2.11,P1＜0.05;t2=3.18,P 2＜0.01).Compared with the controls,the left MT in schizophrenia was increased significantly(t=2.36,P＜0.05),but no difference in right MT(t=0.10,P＞0.05).Conclusion The interhemispheric asymmetries of brain motor cortical excitability in patients with schizophrenia disorder was opposite to the controls,and the left cortical excitability in patients had a evident decrease relative to normal subjects.