中国医药
中國醫藥
중국의약
CHINA MEDICINE
2009年
z1期
26-28
,共3页
非酒精性脂肪性肝炎%多烯磷酯酰胆碱%白细胞介素-6
非酒精性脂肪性肝炎%多烯燐酯酰膽堿%白細胞介素-6
비주정성지방성간염%다희린지선담감%백세포개소-6
Non-alcoholic adipose hepatitis%Polyene phosphorus ester acid radical choline%Interleukin-6
目的 探讨非酒精性脂肪性肝炎(NASH)患者经多烯磷酯酰胆碱治疗后白细胞介素-6的变化及临床意义.方法 84例NASH患者完全随机分为治疗组和对照组,每组各42例.在改善生活方式、控制体重的基础上,治疗组给予多烯磷酯酰胆碱,对照组给予维生素E,治疗12周.比较两组间治疗前后血清中ALT、AST、GGT、IL-6水平的变化.结果 与对照组比较,治疗组治疗后血清ALT、AST、GGT、IL-6水平显著降低(t=4.784、3.334、2.712、3.655,P<0.01),IL-6与ALT、AST、GGT呈显著正相关(β=0.658,0.598,0.634,P<0.01).结论 多烯磷酯酰胆碱治疗可降低血清IL-6水平,促进NASH患者的肝功能改善.
目的 探討非酒精性脂肪性肝炎(NASH)患者經多烯燐酯酰膽堿治療後白細胞介素-6的變化及臨床意義.方法 84例NASH患者完全隨機分為治療組和對照組,每組各42例.在改善生活方式、控製體重的基礎上,治療組給予多烯燐酯酰膽堿,對照組給予維生素E,治療12週.比較兩組間治療前後血清中ALT、AST、GGT、IL-6水平的變化.結果 與對照組比較,治療組治療後血清ALT、AST、GGT、IL-6水平顯著降低(t=4.784、3.334、2.712、3.655,P<0.01),IL-6與ALT、AST、GGT呈顯著正相關(β=0.658,0.598,0.634,P<0.01).結論 多烯燐酯酰膽堿治療可降低血清IL-6水平,促進NASH患者的肝功能改善.
목적 탐토비주정성지방성간염(NASH)환자경다희린지선담감치료후백세포개소-6적변화급림상의의.방법 84례NASH환자완전수궤분위치료조화대조조,매조각42례.재개선생활방식、공제체중적기출상,치료조급여다희린지선담감,대조조급여유생소E,치료12주.비교량조간치료전후혈청중ALT、AST、GGT、IL-6수평적변화.결과 여대조조비교,치료조치료후혈청ALT、AST、GGT、IL-6수평현저강저(t=4.784、3.334、2.712、3.655,P<0.01),IL-6여ALT、AST、GGT정현저정상관(β=0.658,0.598,0.634,P<0.01).결론 다희린지선담감치료가강저혈청IL-6수평,촉진NASH환자적간공능개선.
Objective To observe the change and the clinical significance of IL-6 in patients with non-alcoholic adipose hepatitis(NASH) after being treated with polyene phosphorus ester acid radical choline. Methods Eighty-four patients with NASH were divided into treatment and control groups, with 42 patients in each group. All patients were received both dietary control and life style improvement. The patients in treatment group were treated with polyene phosphorus ester acid radical choline. The patients in the control group were treated with vitaminE pills. Before treatment and after treatment 12 weeks, the changes of serum levels of ALT, AST, GGT, IL-6 were compared. Results After treatment, the serum levels of ALT, AST,GGT, IL-6 of the patients in the treatment group were marked decreased as compared with those in the control group(t=4.784,3.334,2.712,3.655,P<0.01). IL-6 was closely related to ALT, AST and GGT(β=0.658,0.598,0.634,P<0.01). Conclusion Polyene phosphorus ester acid radical choline can decrease the serum levels of IL-6 and improve liver function in patients with NASH.
