中国小儿急救医学
中國小兒急救醫學
중국소인급구의학
CHINESE PEDIATRIC EMERGENCY MEDICINE
2012年
1期
35-37
,共3页
川崎病%循环内皮细胞%冠状动脉损伤
川崎病%循環內皮細胞%冠狀動脈損傷
천기병%순배내피세포%관상동맥손상
Kawasaki disease%Circulating endothelial cells%Coronary artery lesion
目的 通过观察川崎病患儿外周血循环内皮细胞(circulating endothelial cell,CEC)水平的变化与患儿冠状动脉损伤(coronary artery lesion,CAL)的关系,进一步探讨川崎病早期诊断的方法.方法 研究对象为30例川崎病患儿,其中23例为完全型川崎病,7例为不完全型川崎病.根据超声心动图检查结果将川崎病组又分为CAL组9例和冠状动脉无损伤(non-coronary artery lesion,NCAL)组21例.对照组为10例健康体检儿童.采用双盲对照研究法,利用Hladovec法计数CEC.结果 川崎病组患儿CEC为(1.09 ±0.60)×107/L,高于正常对照组[(0.38±0.14)×107/L],差异有统计学意义(t=2.85,P＜0.01).CAL组患儿CEC为(1.84±0.24)×107/L,高于NCAL组[(2.01±0.38)×107/L],差异有统计学意义(t=2.24,P＜0.05).完全型川崎病组患儿CEC数量为(1.16±0.63)×107/L,不完全型川崎病组患儿CEC数量为(0.83±0.45)×107/L,两组差异无统计学意义(t=1.86,P＞0.05).结论 川崎病急性期患儿CEC水平升高明显,急性期CAL组CEC水平高于NCAL组,CEC水平的检测有助于川崎病的早期诊断.
目的 通過觀察川崎病患兒外週血循環內皮細胞(circulating endothelial cell,CEC)水平的變化與患兒冠狀動脈損傷(coronary artery lesion,CAL)的關繫,進一步探討川崎病早期診斷的方法.方法 研究對象為30例川崎病患兒,其中23例為完全型川崎病,7例為不完全型川崎病.根據超聲心動圖檢查結果將川崎病組又分為CAL組9例和冠狀動脈無損傷(non-coronary artery lesion,NCAL)組21例.對照組為10例健康體檢兒童.採用雙盲對照研究法,利用Hladovec法計數CEC.結果 川崎病組患兒CEC為(1.09 ±0.60)×107/L,高于正常對照組[(0.38±0.14)×107/L],差異有統計學意義(t=2.85,P＜0.01).CAL組患兒CEC為(1.84±0.24)×107/L,高于NCAL組[(2.01±0.38)×107/L],差異有統計學意義(t=2.24,P＜0.05).完全型川崎病組患兒CEC數量為(1.16±0.63)×107/L,不完全型川崎病組患兒CEC數量為(0.83±0.45)×107/L,兩組差異無統計學意義(t=1.86,P＞0.05).結論 川崎病急性期患兒CEC水平升高明顯,急性期CAL組CEC水平高于NCAL組,CEC水平的檢測有助于川崎病的早期診斷.
목적 통과관찰천기병환인외주혈순배내피세포(circulating endothelial cell,CEC)수평적변화여환인관상동맥손상(coronary artery lesion,CAL)적관계,진일보탐토천기병조기진단적방법.방법 연구대상위30례천기병환인,기중23례위완전형천기병,7례위불완전형천기병.근거초성심동도검사결과장천기병조우분위CAL조9례화관상동맥무손상(non-coronary artery lesion,NCAL)조21례.대조조위10례건강체검인동.채용쌍맹대조연구법,이용Hladovec법계수CEC.결과 천기병조환인CEC위(1.09 ±0.60)×107/L,고우정상대조조[(0.38±0.14)×107/L],차이유통계학의의(t=2.85,P＜0.01).CAL조환인CEC위(1.84±0.24)×107/L,고우NCAL조[(2.01±0.38)×107/L],차이유통계학의의(t=2.24,P＜0.05).완전형천기병조환인CEC수량위(1.16±0.63)×107/L,불완전형천기병조환인CEC수량위(0.83±0.45)×107/L,량조차이무통계학의의(t=1.86,P＞0.05).결론 천기병급성기환인CEC수평승고명현,급성기CAL조CEC수평고우NCAL조,CEC수평적검측유조우천기병적조기진단.
Objective To investigate the relationship between the change of circulating endothelial cell (CEC) level and coronary artery lesion (CAL) of Kawasaki disease (KD),and to further explore the method for early diagnosis of KD.Methods Thirty KD children were recruited for study,including 23 children with complete type of KD and seven children with incomplete KD.According to the results of echocardiography,the KD group was divided into CAL group (9 cases) and non-coronary artery lesion (NCAL)group (21 cases).Ten healthy children were enrolled as control group.Double-blind and controlled trial was conducted,and Hladovec method was applied for CEC counting.Results The CEC level was ( 1.09 ±0.60) × 107/L in KD group,which was higher than that of control group [ (0.38 ±0.14) × 107/L],and the difference was statistically significant ( t =2.85,P ＜ 0.01 ).The CEC level in the CAL group [ ( 1.84 ± 0.24) × 107/L] was higher than that of the NCAL group[ (2.01 ±0.38) × 107/L],and the difference was statistically significant ( t =2.24,P ＜ 0.05 ).The CEC level was ( 1.16 ± 0.63 ) × 107/L in the complete type of KD group and (0.83 ± 0.45 ) × 107/L in the incomplete KD group,which showed no significant difference between the two groups ( t =1.86,P ＞ 0.05 ).Condusion CEC level was elevated significantly in the acute phase of KD.The CEC level in CAL group was higher than that of NCAL group in acute phase.CEC level detection may be helpful for the early diagnosis of KD.
