中国医药
中國醫藥
중국의약
CHINA MEDICINE
2012年
10期
1245-1247
,共3页
陈宇%陈奇松%许俊凯%方建禅
陳宇%陳奇鬆%許俊凱%方建禪
진우%진기송%허준개%방건선
食管癌%表皮生长因子受体%血管内皮生长因子%环氧化酶2
食管癌%錶皮生長因子受體%血管內皮生長因子%環氧化酶2
식관암%표피생장인자수체%혈관내피생장인자%배양화매2
Esophageal carcinoma%Epidermal growth factor receptor%Vascular endothelial growth factors%Cyclooxygenase-2
目的 研究食管癌中表皮生长因子受体(EGFR)、血管内皮生长因子(VEGF)、环氧化酶2(COX-2)的表达及其与肿瘤组织病理特征之间的关系.方法 应用免疫组化的方法分别检测94例食管癌组织和30例邻近正常食管黏膜中EGFR、VEGF蛋白、COX-2蛋白表达水平,并分析三者与肿瘤组织病理特征之间的关系.结果 EGFR、VEGF、COX-2在94例食管癌组织中阳性表达率分别为69.2％(65/94)、73.4％(69/94)、84.0％(79/94)；而在30例正常食管黏膜中阳性表达率分别为13.3％(4/30)、13.3％(4/30)、3.3％(1/30),2组间表达差异有统计学意义(P＜0.01)；且EGFR、VEGF、COX-2与淋巴结转移和TNM分期有关(P＜0.05).结论 EGFR、VEGF、COX-2在食管癌组织中显著表达,且可能参与肿瘤发生、发展,可作为预测食管癌生物学行为的重要参考指标.
目的 研究食管癌中錶皮生長因子受體(EGFR)、血管內皮生長因子(VEGF)、環氧化酶2(COX-2)的錶達及其與腫瘤組織病理特徵之間的關繫.方法 應用免疫組化的方法分彆檢測94例食管癌組織和30例鄰近正常食管黏膜中EGFR、VEGF蛋白、COX-2蛋白錶達水平,併分析三者與腫瘤組織病理特徵之間的關繫.結果 EGFR、VEGF、COX-2在94例食管癌組織中暘性錶達率分彆為69.2％(65/94)、73.4％(69/94)、84.0％(79/94)；而在30例正常食管黏膜中暘性錶達率分彆為13.3％(4/30)、13.3％(4/30)、3.3％(1/30),2組間錶達差異有統計學意義(P＜0.01)；且EGFR、VEGF、COX-2與淋巴結轉移和TNM分期有關(P＜0.05).結論 EGFR、VEGF、COX-2在食管癌組織中顯著錶達,且可能參與腫瘤髮生、髮展,可作為預測食管癌生物學行為的重要參攷指標.
목적 연구식관암중표피생장인자수체(EGFR)、혈관내피생장인자(VEGF)、배양화매2(COX-2)적표체급기여종류조직병리특정지간적관계.방법 응용면역조화적방법분별검측94례식관암조직화30례린근정상식관점막중EGFR、VEGF단백、COX-2단백표체수평,병분석삼자여종류조직병리특정지간적관계.결과 EGFR、VEGF、COX-2재94례식관암조직중양성표체솔분별위69.2％(65/94)、73.4％(69/94)、84.0％(79/94)；이재30례정상식관점막중양성표체솔분별위13.3％(4/30)、13.3％(4/30)、3.3％(1/30),2조간표체차이유통계학의의(P＜0.01)；차EGFR、VEGF、COX-2여림파결전이화TNM분기유관(P＜0.05).결론 EGFR、VEGF、COX-2재식관암조직중현저표체,차가능삼여종류발생、발전,가작위예측식관암생물학행위적중요삼고지표.
Objective To investigate the expression of epidermal growth factor receptor(EGFR),vascular endothelial growth factor(VEGF)and cyclooxygenase-2(COX-2)in esophageal carcinoma(EC)and their relationships with clinicopathologic features. Methods Using immunohistochemical methods,we assessed the expression levels of EGFR,VEGF and COX-2 in 94 surgically resected specimens from patients with EC and 30 normal contiguous esophageal mucosa specimens.We also explored the relationship between the histopathologic features and the expression levels of EGFR,VEGF and COX-2.Results The positive rates of EGFR,VEGF and COX-2 expressions were 13.3％(4/30),13.3％(4/30),3.3％(1/30)in normal mucosa and 69.2％(65/94),73.4％(69/94),84.0％(79/94)in EC respectively.There were significant differences between the two groups (P＜0.01). In EC,high EGFR,VEGF and COX-2 expressions had a positive correlation with tumor node metastases classification and lymph node metastasis(P ＜ 0.05).Conclusions EGFR,VEGF and COX-2 are overexpressed in EC.They might participate in tumorigenesis and progression. Over-expression of EGFR,VEGF and COX-2 can be used as a biological marker to evaluate the behavior of EC.
