中华泌尿外科杂志
中華泌尿外科雜誌
중화비뇨외과잡지
CHINESE JOURNAL OF UROLOGY
2011年
2期
115-118
,共4页
杨国良%张连华%薄隽杰%侯恺林%朱寅杰%张超%蒋海锋%刘东明%黄翼然
楊國良%張連華%薄雋傑%侯愷林%硃寅傑%張超%蔣海鋒%劉東明%黃翼然
양국량%장련화%박준걸%후개림%주인걸%장초%장해봉%류동명%황익연
膀胱肿瘤%高迁移率族蛋白A2%免疫组化%诊断%预后
膀胱腫瘤%高遷移率族蛋白A2%免疫組化%診斷%預後
방광종류%고천이솔족단백A2%면역조화%진단%예후
Bladder cancer%HMGA2%Immunohistochemistry%Diagnosis%Prognosis
目的 探讨高迁移率族蛋白A2(high mobility group protein A2,HMGA2)在膀胱癌组织中的表达情况,并分析其与临床病理特征及复发的关系.方法 膀胱尿路上皮癌标本148例,正常膀胱组织标本30例,采用免疫组织化学方法检测2组标本组织中HMGA2蛋白的表达,并结合临床资料进行分析.结果 正常膀胱组织中无HMGA2蛋白表达,肿瘤组织中随病理分级和分期增加,HMGA2蛋白相对表达量逐渐增高.HMGA2蛋白在G1、G2、G3组织中表达阳性率分别为21.3%、60.3%、82.1%,差异有统计学意义(P＜0.001).非肌层浸润性膀胱尿路上皮癌和肌层浸润性膀胱尿路上皮癌中HMGA2蛋白表达的阳性率分别为43.3%和72.7%,差异有统计学意义(P=0.003).随访2～95个月,复发64例,复发组与未复发组中HMGA2蛋白表达阳性率分别为54.7%和25.0%,差异有统计学意义(P=0.007).结论 HMGA2蛋白表达在膀胱癌组织中明显高于正常组织,HMGA2蛋白表达与膀胱癌的分级、分期、复发有关;与患者年龄、性别、肿瘤数目无相关性.检测HMGA2蛋白有助于膀胱癌的诊断及预后的评估.
目的 探討高遷移率族蛋白A2(high mobility group protein A2,HMGA2)在膀胱癌組織中的錶達情況,併分析其與臨床病理特徵及複髮的關繫.方法 膀胱尿路上皮癌標本148例,正常膀胱組織標本30例,採用免疫組織化學方法檢測2組標本組織中HMGA2蛋白的錶達,併結閤臨床資料進行分析.結果 正常膀胱組織中無HMGA2蛋白錶達,腫瘤組織中隨病理分級和分期增加,HMGA2蛋白相對錶達量逐漸增高.HMGA2蛋白在G1、G2、G3組織中錶達暘性率分彆為21.3%、60.3%、82.1%,差異有統計學意義(P＜0.001).非肌層浸潤性膀胱尿路上皮癌和肌層浸潤性膀胱尿路上皮癌中HMGA2蛋白錶達的暘性率分彆為43.3%和72.7%,差異有統計學意義(P=0.003).隨訪2～95箇月,複髮64例,複髮組與未複髮組中HMGA2蛋白錶達暘性率分彆為54.7%和25.0%,差異有統計學意義(P=0.007).結論 HMGA2蛋白錶達在膀胱癌組織中明顯高于正常組織,HMGA2蛋白錶達與膀胱癌的分級、分期、複髮有關;與患者年齡、性彆、腫瘤數目無相關性.檢測HMGA2蛋白有助于膀胱癌的診斷及預後的評估.
목적 탐토고천이솔족단백A2(high mobility group protein A2,HMGA2)재방광암조직중적표체정황,병분석기여림상병리특정급복발적관계.방법 방광뇨로상피암표본148례,정상방광조직표본30례,채용면역조직화학방법검측2조표본조직중HMGA2단백적표체,병결합림상자료진행분석.결과 정상방광조직중무HMGA2단백표체,종류조직중수병리분급화분기증가,HMGA2단백상대표체량축점증고.HMGA2단백재G1、G2、G3조직중표체양성솔분별위21.3%、60.3%、82.1%,차이유통계학의의(P＜0.001).비기층침윤성방광뇨로상피암화기층침윤성방광뇨로상피암중HMGA2단백표체적양성솔분별위43.3%화72.7%,차이유통계학의의(P=0.003).수방2～95개월,복발64례,복발조여미복발조중HMGA2단백표체양성솔분별위54.7%화25.0%,차이유통계학의의(P=0.007).결론 HMGA2단백표체재방광암조직중명현고우정상조직,HMGA2단백표체여방광암적분급、분기、복발유관;여환자년령、성별、종류수목무상관성.검측HMGA2단백유조우방광암적진단급예후적평고.
Objective This study was to explore the expression and significance of HMA2 in bladder cancer , analyze its correlations to clinicopathologic and recurrence of bladder cancer. Methods The expression of HMGA2 protein in 148 specimens of bladder cancer and 30 specimens of normal bladder tissues was detected by immunohistochemtry, its correlations to clinicopathologic features was analyzed. Results There was no expression of HMGA2 protein in normal bladder tissues,while the expression level of HMGA2 protein was getting higher with the increase of tumor pathology grade and stage. The positive rate of HMGA2 protein was 21.3% in G1 bladder cancer, 60. 3% in G2 bladder cancer, 82.1% in G3 bladder cancer, its difference is significant (P＜0. 001). It was significantly lower in non-muscle invasive bladder cancer than in muscle invasive bladder cancer (43.3% vs 72. 7%, P=0. 003). The patients were followed up for 2～95 months, patients of recurrence was 64,HMGA2 protein expression was significantly higher in patients with recurrence than with non-recurrence (54.7% vs 25.0%, P=0. 007). Conclusions The expression of HMGA2 protein was highly in bladder cancer, the positive rate of HMGA2 protein expression was related with classification,TMN stage and recurrence, but not with sex, age, tumor number (P＞0. 05). The detection of the expression of HMGA2 protein is in favor of diagnosis and prognostic evaluation of bladder cancer.
