中华实验和临床病毒学杂志
中華實驗和臨床病毒學雜誌
중화실험화림상병독학잡지
CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL VIROLOGY
2012年
2期
127-129
,共3页
严颖%麦丽%张英%江元森%徐启桓
嚴穎%麥麗%張英%江元森%徐啟桓
엄영%맥려%장영%강원삼%서계환
肝炎,乙型,慢性%肝肾综合征%预后%模型,统计学
肝炎,乙型,慢性%肝腎綜閤徵%預後%模型,統計學
간염,을형,만성%간신종합정%예후%모형,통계학
Hepatitis B,chronic%Hepatorenal syndrome%Prognosis%Models,statistical
目的 研究影响肝肾综合征预后的因素、建立预后判断模型.方法 选择126例肝肾综合征的病例,观察56项可能与本病预后有关的指标,涉及个人情况、病史、症状、体征、实验室检查等方面,用COX比例风险模型及Kaplan-Meier进行分析.结果 肝性脑病(HE)及其程度、消化道出血(GIB)、血中性粒细胞数(N1)、肌酐(Cr)是影响预后的独立因素.危险指数PI=0.711HE+0.836GIB+0.052N1+0.002Cr( N1、Cr为原测值；消化道出血,有=1,无=0；肝性脑病,无=0,Ⅰ期=1,Ⅱ期=2,Ⅲ=3,Ⅳ期=4).当PI＜1时,平均生存期42 d；1≤PI≤3,平均生存期15 d；PI＞3,平均生存期2d.结论 肝性脑病及其程度、消化道出血、血中性粒细胞数、肌酐是影响预后的独立因素,可用于建立预后判断模型,本预后模型在临床工作中有助干预后判断、疗效评价,在治疗研究中可用于设定配对对照组.
目的 研究影響肝腎綜閤徵預後的因素、建立預後判斷模型.方法 選擇126例肝腎綜閤徵的病例,觀察56項可能與本病預後有關的指標,涉及箇人情況、病史、癥狀、體徵、實驗室檢查等方麵,用COX比例風險模型及Kaplan-Meier進行分析.結果 肝性腦病(HE)及其程度、消化道齣血(GIB)、血中性粒細胞數(N1)、肌酐(Cr)是影響預後的獨立因素.危險指數PI=0.711HE+0.836GIB+0.052N1+0.002Cr( N1、Cr為原測值；消化道齣血,有=1,無=0；肝性腦病,無=0,Ⅰ期=1,Ⅱ期=2,Ⅲ=3,Ⅳ期=4).噹PI＜1時,平均生存期42 d；1≤PI≤3,平均生存期15 d；PI＞3,平均生存期2d.結論 肝性腦病及其程度、消化道齣血、血中性粒細胞數、肌酐是影響預後的獨立因素,可用于建立預後判斷模型,本預後模型在臨床工作中有助榦預後判斷、療效評價,在治療研究中可用于設定配對對照組.
목적 연구영향간신종합정예후적인소、건립예후판단모형.방법 선택126례간신종합정적병례,관찰56항가능여본병예후유관적지표,섭급개인정황、병사、증상、체정、실험실검사등방면,용COX비례풍험모형급Kaplan-Meier진행분석.결과 간성뇌병(HE)급기정도、소화도출혈(GIB)、혈중성립세포수(N1)、기항(Cr)시영향예후적독립인소.위험지수PI=0.711HE+0.836GIB+0.052N1+0.002Cr( N1、Cr위원측치；소화도출혈,유=1,무=0；간성뇌병,무=0,Ⅰ기=1,Ⅱ기=2,Ⅲ=3,Ⅳ기=4).당PI＜1시,평균생존기42 d；1≤PI≤3,평균생존기15 d；PI＞3,평균생존기2d.결론 간성뇌병급기정도、소화도출혈、혈중성립세포수、기항시영향예후적독립인소,가용우건립예후판단모형,본예후모형재림상공작중유조간예후판단、료효평개,재치료연구중가용우설정배대대조조.
Objective To identify the factors that may influence the prognosis of patients with hepatorenal syndrome and try to establish a prognostic model.Methods Data of 126 patients with hepatorenal syndrome were analyzed and 56 indexes that might affect the prognosis were focused on,involving history,symptoms,signs and lab findings.Cox model and Kaplan-Meier survival analysis were used.Results Many factors were found to affect the prognosis independently, including hepatic encephalopathy (HE) and its degree,gastrointestinal bleeding( GIB ),blood neutrophil count (NI) and serum creatinine (Cr).The prognosis model was established as the following equation where PI represents prognosis index:PI =0.711HE + 0.836GIB + 0.052N1 + 0.002Cr ( GIB:no =0,yes =1 ; HE:no =0,phase Ⅰ =1,phase Ⅱ =2,phase Ⅲ =3,phase Ⅳ =4 ).When PI ＜ 1,the average survival time was 42 days; when 1 ≤ PI≤ 3,the average survival time was 15 days; when PI ＞ 3,the average survival time was 2 days.Conclusion The resuhs obtained from this study may help in estimation of diagnosis,analys01is of illness state and evaluation of therapy in clinical work.
