肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2012年
5期
316-317,327
,共3页
田子农%温端改%何小舟%徐仁芳%许贤林%侯建全%浦金贤
田子農%溫耑改%何小舟%徐仁芳%許賢林%侯建全%浦金賢
전자농%온단개%하소주%서인방%허현림%후건전%포금현
膀胱肿瘤%综合疗法%疗效比较研究
膀胱腫瘤%綜閤療法%療效比較研究
방광종류%종합요법%료효비교연구
Urinary bladder neoplasms%Combined modality therapy%Comparative effectiveness research
目的 探讨保留膀胱的局部切除联合动脉化疗治疗T1G3膀胱尿路上皮癌的疗效.方法 对35例T1G3膀胱尿路上皮癌患者行保留膀胱的肿瘤切除,术后辅助3次动脉化疗,所有患者均行规范膀胱灌注化疗.结果 35例患者术后随访7～ 116个月,平均随访(66.0±18.3)个月,术后5年肿瘤复发率48.6％(17/35),膀胱保留率68.6％(24/35),总生存率77.1％(27/35),肿瘤特异性生存率82.9％(29/35),动脉化疗无严重并发症发生.结论 T1G3膀胱尿路上皮癌保留膀胱综合治疗不但可以维持正常的膀胱功能,降低复发率,而且不会降低患者的生存率,是可选择的有效治疗手段,避免部分患者行膀胱全切的过度治疗.
目的 探討保留膀胱的跼部切除聯閤動脈化療治療T1G3膀胱尿路上皮癌的療效.方法 對35例T1G3膀胱尿路上皮癌患者行保留膀胱的腫瘤切除,術後輔助3次動脈化療,所有患者均行規範膀胱灌註化療.結果 35例患者術後隨訪7～ 116箇月,平均隨訪(66.0±18.3)箇月,術後5年腫瘤複髮率48.6％(17/35),膀胱保留率68.6％(24/35),總生存率77.1％(27/35),腫瘤特異性生存率82.9％(29/35),動脈化療無嚴重併髮癥髮生.結論 T1G3膀胱尿路上皮癌保留膀胱綜閤治療不但可以維持正常的膀胱功能,降低複髮率,而且不會降低患者的生存率,是可選擇的有效治療手段,避免部分患者行膀胱全切的過度治療.
목적 탐토보류방광적국부절제연합동맥화료치료T1G3방광뇨로상피암적료효.방법 대35례T1G3방광뇨로상피암환자행보류방광적종류절제,술후보조3차동맥화료,소유환자균행규범방광관주화료.결과 35례환자술후수방7～ 116개월,평균수방(66.0±18.3)개월,술후5년종류복발솔48.6％(17/35),방광보류솔68.6％(24/35),총생존솔77.1％(27/35),종류특이성생존솔82.9％(29/35),동맥화료무엄중병발증발생.결론 T1G3방광뇨로상피암보류방광종합치료불단가이유지정상적방광공능,강저복발솔,이차불회강저환자적생존솔,시가선택적유효치료수단,피면부분환자행방광전절적과도치료.
Objective To evaluate the feasibility and effectiveness of bladder-preserving local resection combined with intra-artery chemotherapy for patients with T1G3 bladder cancer.Methods Thirty five cases with T1G3 bladder cancer were analyzed retrospectively. Patients were all treated by bladder-preserving local resection combined with intra-artery chemotherapy. Results Thirty five cases were followed up. The time of follow-up ranged from 7 to 116 months,and mean time was(66.0±18.3)months.The 5 year recurrence and bladder-preserving rate were 48.6 ％(17/35)and 68.6 ％(24/35),respectively.The overall and tumor specific survival at 5 years was 77.1％ (27/35)and 82.9 ％ (29/35).The effect of bladder-preserving local resection plus intra-artery chemotherapy was satisfactory. Moreover, intra-artery chemotherapy had no obvious side effects.Conclusion Bladder-preserving local resection combined with intra-artery chemotherapy not only can retain normal bladder function, decrease in the recurrence, but also does not reduce the survival rate. It is an effective treatment for some patients with T1G3 bladder cancer instead of cystectomy over-treatment.
