CAJ | 학술논문

目的研究表皮生长因子受体(EGFR)在涎腺腺样囊性癌(SACC)中的表达,探讨EGFR的表达与SACC临床病理特征的关系及其在肿瘤侵袭中的作用.方法收集54例SACC患者的临床病理资料,采用免疫组化SP法检测EGFR在SACC组织中的表达,分析EGFR表达与SACC临床病理特征的关系.结果 EGFR在SACC组织中的表达主要分布于细胞膜和细胞浆中.在54例SACC患者中,EGFR的阳性表达率为75.9％；而在正常涎腺组织中,EGFR表达不明显或仅在腺管周围的腺泡细胞内微量表达,阳性表达率为10.0％,两组比较差异有统计学意义(P＜0.05).EGFR的表达与SACC的T分期、组织学类型、远处转移、淋巴结转移、神经侵犯有关(均P＜0.05).结论 EGFR在胞浆中的高水平表达可能在侵袭癌的进展中发挥重要作用,对其深入研究有望为腺样囊性癌的治疗带来新的策略.
목적 연구표피생장인자수체(EGFR)재연선선양낭성암(SACC)중적표체,탐토EGFR적표체여SACC림상병리특정적관계급기재종류침습중적작용.방법 수집54례SACC환자적림상병리자료,채용면역조화SP법검측EGFR재SACC조직중적표체,분석EGFR표체여SACC림상병리특정적관계.결과 EGFR재SACC조직중적표체주요분포우세포막화세포장중.재54례SACC환자중,EGFR적양성표체솔위75.9％；이재정상연선조직중,EGFR표체불명현혹부재선관주위적선포세포내미량표체,양성표체솔위10.0％,량조비교차이유통계학의의(P＜0.05).EGFR적표체여SACC적T분기、조직학류형、원처전이、림파결전이、신경침범유관(균P＜0.05).결론 EGFR재포장중적고수평표체가능재침습암적진전중발휘중요작용,대기심입연구유망위선양낭성암적치료대래신적책략.
Objective To assess the epidermal growth factor receptor (EGFR) status in salivary adenoid cystic carcinoma and explore its role in cancer invasion. Methods Fifty-four patients with pathologically confirmed salivary adenoid cystic carcinoma (SACC) were divided into invasion group and non-invasion group.The EGFR expression was determined by immunohistochemstry (SP staining). The relations between the EGFR expression and the SACC clinical pathological characteristics were analyzed.Results EGFR were mainly expressed in the cell membrane and cytoplasm in the tissue of SACC.The positive rate of EGFR expression in the tumor tissue was 75.9％ (41/54),and EGFR was over-expressed in the cytoplasm.The positive rate of EGFR expression in invasion group was higher than that in the noninvasion group ( 10.0％,P ＜ 0.05 ).EGFR expression were related with the SACC T stages,histological types,distant metastasis,lymph node metastasis,and nerve invasion ( P ＜ 0.05).Conclusions A higher expression of EGFR gene in the cytoplasm may have important effect on the progression of invasive carcinoma.Further investigations are required to develop new strategy in the treatment of salivary adenoid cystic carcinoma.