CAJ | 학술논문

目的新生儿高胆红素血症患儿常出现胃肠道症状.该研究目的是探讨高胆红素血症(高胆)对新生儿胃肠激素水平的影响及其可能的发生机制.方法应用放射免疫分析法(RIA)对50例高胆患儿空腹状态下血中胃动素、胃泌素浓度进行测定,并以30例正常新生儿作为对照.结果高胆组患儿血浆胃动素浓度(659±37ng/L)明显高于对照组(486±28ng/L),差异有显著性意义(P＜0.01),且与血清胆红素水平呈正相关;血清胃泌素浓度(128±9 ng/L)与对照组(132±11ng/L)比较差异无显著性(P＞0.05).结论高胆红素血症新生儿的某些胃肠道症状可能与胃动素分泌异常有关.
목적신생인고담홍소혈증환인상출현위장도증상.해연구목적시탐토고담홍소혈증(고담)대신생인위장격소수평적영향급기가능적발생궤제.방법응용방사면역분석법(RIA)대50례고담환인공복상태하혈중위동소、위비소농도진행측정,병이30례정상신생인작위대조.결과고담조환인혈장위동소농도(659±37ng/L)명현고우대조조(486±28ng/L),차이유현저성의의(P＜0.01),차여혈청담홍소수평정정상관;혈청위비소농도(128±9 ng/L)여대조조(132±11ng/L)비교차이무현저성(P＞0.05).결론고담홍소혈증신생인적모사위장도증상가능여위동소분비이상유관.
Objective Most newborn infants with hyperbilirubinemia have gastrointestinal tract symptoms. The aim of this study is to investigate the effect of hyperbilirubinemia on gastrointestinal hormone levels in newborn infants.Methods Fasting plasma motilin and serum gastrin levels were measured using a radioimmunoassay in 50 term newborns with hyperbilirubinemia (Hyperbilirubinemia group). Fasting plasm motilin and serum gastrin levels from thirty normal term newborns were used as controls. Results The plasma motilin level in the Hyperbilirubinemia group (659 ± 37 ng/L) was significantly higher than that of the controls (486 ± 28 ng/L) ( P ＜ 0.01). The plasma motilin level was positively correlated with the serum bilirubin level. The serum gastrin level in the Hyperbilirubinema group was not different from that of the controls. Conclusions The plasma motilin level is correlated with the level of bilirubin in the newborn. The abnormal increase in the level of motilin may be related to the development of gastrointestinal symptoms newborns with hyperbilirubinemia.