CAJ | 학술논문

目的:研究水黄皮根乙醇提取物的抗炎镇痛作用及其急性毒性.方法:抗炎实验采用二甲苯致小鼠耳肿胀法及大鼠棉球肉芽肿法;镇痛实验采用小鼠热板和醋酸扭体实验;采用Bliss法测定了其半数致死量(LD50).结果:PRE可明显抑制二甲苯所致小鼠耳廓的肿胀度,抑制大鼠棉球肉芽肿的增长;可明显对抗醋酸所致小鼠的扭体次数增加,提高热板所致小鼠的痛阈值;其LD50为6.3718g/kg,LD50的95%平均可信限为5.4084～7.7232g/kg.结论:水黄皮根乙醇提取物具有明显抗炎镇痛作用,并且其急性毒性很小.
목적:연구수황피근을순제취물적항염진통작용급기급성독성.방법:항염실험채용이갑분치소서이종창법급대서면구육아종법;진통실험채용소서열판화작산뉴체실험;채용Bliss법측정료기반수치사량(LD50).결과:PRE가명현억제이갑분소치소서이곽적종창도,억제대서면구육아종적증장;가명현대항작산소치소서적뉴체차수증가,제고열판소치소서적통역치;기LD50위6.3718g/kg,LD50적95%평균가신한위5.4084～7.7232g/kg.결론:수황피근을순제취물구유명현항염진통작용,병차기급성독성흔소.
AIM: To study the effect of extract from Pongamia pinnata roots on anti-inflammation and analgesia and acute toxicity. METHODS: The models of mice ear edema induced by xylene and Cotton pellet granuloma in rats to observe the anti-inflammation effect of PRE via oral administration. The effect of PRE on analgesia was tested by measuring the latent period licking hind foot with the hot plate method and counting body twisting induced by acetic acid in mice. The acute toxicity of PRE was measured by the method of Bliss. RESULTS: PRE could significantly inhibit the ear edema caused by xylene in mice, granuloma hyperplasia caused by cotton in rats. It could significantly prolong the pain threshold on hot-plate in mice, reduce the writhing times in mice. The LD50 of PRE was 6. 371 8 g/kg, its 95% confident limit was 5. 408 4-7. 723 2 g/kg. CONCLUSION: PRE has obvious effect on anti-inflammation and analgesia and the lower acute toxicity.