CAJ | 학술논문

实验研究西藏芫根提取物的抗缺氧活性.通过建立小鼠常压缺氧模型、急性脑缺血性缺氧模型以及亚硝酸钠中毒模型,以蒸馏水作为空白对照,盐酸普萘洛尔作为阳性对照,观察芫根水、65%乙醇及95%乙醇提取物的10 g/kg、15 g/kg和20 g/kg剂量组对小鼠缺氧的保护作用,同时观察各提取物10 g/kg剂量组对红细胞数量和血红蛋白含量的影响.结果表明,芫根水提取物、65%乙醇提取物及95%乙醇提取物均能明显延长模型小鼠在常压缺氧、急性脑缺血性缺氧及亚硝酸钠中毒时的存活时间,并可增加外周血象中红细胞数与血红蛋白含量,显示芫根提取物具有抗缺氧活性.
실험연구서장원근제취물적항결양활성.통과건립소서상압결양모형、급성뇌결혈성결양모형이급아초산납중독모형,이증류수작위공백대조,염산보내락이작위양성대조,관찰원근수、65%을순급95%을순제취물적10 g/kg、15 g/kg화20 g/kg제량조대소서결양적보호작용,동시관찰각제취물10 g/kg제량조대홍세포수량화혈홍단백함량적영향.결과표명,원근수제취물、65%을순제취물급95%을순제취물균능명현연장모형소서재상압결양、급성뇌결혈성결양급아초산납중독시적존활시간,병가증가외주혈상중홍세포수여혈홍단백함량,현시원근제취물구유항결양활성.
The effect of Bassia rapa L. extract on anti-hypoxia was investigated. Using distilled water as a blank control and propranolol hydrochloride as a positive control, the survival time of mice in hypoxia under ordinary pressures, and with acute cerebral ischemia and sodium nitrite were used to evaluate the anti-hypoxic effect of three different doses (10, 15, 20 g/kg) of 65%, 95% alcohol extract and water extract of Bassia rapa L. Erythrocyte number and hemoglobin count were used to investigate the anti-hypoxic effect of 65%, 95% alcohol extract and water extract (10 g/kg) of Bassia rapa L. The result indicates that Bassia rapa L. 65%, 95% alcohol extract and water extract can prolong the survival time of mice in hypoxia under ordinary pressures significantly. It can also prolong the survival time of mice with acute cerebral ischemia and sodium nitrite significantly, and increase the number of erythrocytes and the content of hemoglobin. It demonstrates that Bassia rapa L. extract has anti-hypoxia activity.