CAJ | 학술논문

动脉粥样硬化是冠状动脉疾病、脑血管病和周围动脉病等血管性疾病的重要病理学基础.大量研究显示,粥样硬化斑块好发于动脉开口、分叉和弯曲部位,说明血流低切应力与动脉粥样硬化的发生密切相关.血流低切应力通过作用于血管内皮细胞机械力感受器分子,并将机械刺激转化为化学信号,激活相应细胞内信号通路,参与诱导动脉粥样硬化.文章就血流低切应力与动脉粥样硬化的关系进行了综述.
동맥죽양경화시관상동맥질병、뇌혈관병화주위동맥병등혈관성질병적중요병이학기출.대량연구현시,죽양경화반괴호발우동맥개구、분차화만곡부위,설명혈류저절응력여동맥죽양경화적발생밀절상관.혈류저절응력통과작용우혈관내피세포궤계력감수기분자,병장궤계자격전화위화학신호,격활상응세포내신호통로,삼여유도동맥죽양경화.문장취혈류저절응력여동맥죽양경화적관계진행료종술.
Atherosclerosis is the important pathologic basis of coronary artery disease,cerebrovascular disease,peripheral arterial disease and other vascular diseases.Studies have shown that the atheromatous plaques occur mainly in regions of curvature,bifurcation,and branching of the artery,indicating that low flow shear stress is closely associated with the occurrence of atherosclerosis.Low flow shear stress involves in the induction of atherosclerosis through acting on mechanosensitive molecules in endothelial cell that transduce mechanical stimuli into chemical signals,activate the corresponding intracellular signaling pathways.This article reviews the relationship between low flow shear stress and atherosclerosis.