CAJ | 학술논문

环氧合酶(cyclooxygenase,COX)是以花生四烯酸为底物合成前列腺素的首要限速酶,COX-2作为其亚型之一,主要受细胞内外的各种刺激因素诱导表达.大量的研究表明,COX-2与血管的发生密切相关,它能够通过其衍生的各种前列腺素来影响血管内皮细胞的增殖与凋亡,并由此来参与各种慢性炎症性疾病和肿瘤的发生.弄清COX-2对血管内皮细胞增殖与凋亡的影响,及其相关的作用机制,有助于我们更好的认识其在疾病发生中的作用,从而避弊取利,为临床治疗提供更多更好的方案.
배양합매(cyclooxygenase,COX)시이화생사희산위저물합성전렬선소적수요한속매,COX-2작위기아형지일,주요수세포내외적각충자격인소유도표체.대량적연구표명,COX-2여혈관적발생밀절상관,타능구통과기연생적각충전렬선소래영향혈관내피세포적증식여조망,병유차래삼여각충만성염증성질병화종류적발생.롱청COX-2대혈관내피세포증식여조망적영향,급기상관적작용궤제,유조우아문경호적인식기재질병발생중적작용,종이피폐취리,위림상치료제공경다경호적방안.
Cyclooxygenase (COX) is the rate-limiting enzyme of arachidonie acid synthesis prostaglandin,COX-2 is the subtype, whose expression can be induced expression by many stumilating factors. Many researches dedicated that COX-2 plays a very important role in angiogenesis,it could affect the vascular endothelial cell's apoptosis and proliferation through prostaglandins derived from it,then participate in the chronic inflammation and tumorigenisis. Understanding the influence of COX-2 to endothelial apoptosis and mechanism of action related,could help us to know what role it plays in the development of the disease, and make rational proposal for the clinical therapy.