CAJ | 학술논문

133例男性2型糖尿病患者以血浆致动脉粥样硬化指数(AIP)0.06为切点分为非致动脉硬化表型组(N组)和致动脉硬化表型组(A组),比较2组间的临床生化指标.结果显示,A组体重指数(BMI)、腰臀比、稳态模型评估的胰岛素抵抗指数(HOMA-IR)和胰岛素分泌指数(HOMA-IS)、甘油三酯(TG)、极低密度脂蛋白胆固醇(VLDL-C)、血尿酸、尿尿酸和尿微量白蛋白(UMA)较N组明显升高(均P＜0.05),高密度脂蛋白胆固醇(HDL-C)降低(P＜0.01),冠心病发病率较高(P＜0.05).相关分析表明,AIP与年龄、BMI、腰臀比、HOMA-IR、HOMA-IS、收缩压、舒张压、TG、总胆固醇、VLDL-C、血尿酸、尿尿酸、UMA正相关(均P＜0.05),与HDL-C负相关(P＜0.01).多元逐步线性回归分析表明,TG、HDL-C、VLDL-C和尿尿酸是AIP的独立影响因素.
133례남성2형당뇨병환자이혈장치동맥죽양경화지수(AIP)0.06위절점분위비치동맥경화표형조(N조)화치동맥경화표형조(A조),비교2조간적림상생화지표.결과현시,A조체중지수(BMI)、요둔비、은태모형평고적이도소저항지수(HOMA-IR)화이도소분비지수(HOMA-IS)、감유삼지(TG)、겁저밀도지단백담고순(VLDL-C)、혈뇨산、뇨뇨산화뇨미량백단백(UMA)교N조명현승고(균P＜0.05),고밀도지단백담고순(HDL-C)강저(P＜0.01),관심병발병솔교고(P＜0.05).상관분석표명,AIP여년령、BMI、요둔비、HOMA-IR、HOMA-IS、수축압、서장압、TG、총담고순、VLDL-C、혈뇨산、뇨뇨산、UMA정상관(균P＜0.05),여HDL-C부상관(P＜0.01).다원축보선성회귀분석표명,TG、HDL-C、VLDL-C화뇨뇨산시AIP적독립영향인소.
133 male patients with type 2 diabetes mellitus were divided into non-atherogenic phenom( N group ) and atherogenic phenom( A group) according to the c utpoint of atherogenic index of plasma (AIP) at 0.06.The clinical chemistry data were compared between two groups.The results showed that body mass index ( BMI ),waist-tohip ratio (WHR),homeostasis model assessment insulin resistance index ( HOMA-IR ) and insulin secretion index (HOMA-IS),serum triglyceride (TG),very low density lipoprotein-cholesterol (VLDL-C),serum uric acid ( SUA ),urine uric acid ( UUA ),and urine micro-albumin ( UMA ) levels in A group were higher than those in N group ( all P＜0.05 ),while high density lipoprotein-cholesterol ( HDL-C ) level was lower ( P＜0.01 ),as well as higher coronary heart disease incidence in A group as compared with N group( P＜0.05 ).Correlation analysis revealed that AIP was positively related with age,BMI,WHR,HOMA-IR,HOMA-IS,systolic blood pressure,diastolic blood poressure,TG,total cholesterol,VLDL-C,SUA,UUA,and UMA( all P＜0.05 ),and negatively related with HDL-C (P＜0.01).Multivariant stepwise linear regression analysis revealed that TG,HDL-C,V LDL-C,and UUA were independent influential factors for AIP.