CAJ | 학술논문

目的探讨病毒性重型肝炎患者血清皮质醇浓度的变化.方法应用放射免疫法测定50例病毒性肝炎患者血清皮质醇浓度.其中重型肝炎患者30例,慢性乙型肝炎患者20例.同时检测患者肝功能、PTA等实验室指标.结果重型肝炎患者组血清皮质醇浓度较慢性乙型肝炎患者组低(P<0.05),较正常对照组低(P<0.05);在重型肝炎患者中,血清皮质醇浓度与PTA呈显著正相关(r=0.445,P<0.05),重型肝炎患者血清皮质醇浓度与患者血清ALT无明显相关性(P>0.05),与AST/ALT比值呈显著负相关(r=-0.367,P<0.05),与患者血清总胆红素无明显相关性(P>0.05);重型肝炎患者死亡组的血清皮质醇浓度明显低于存活组(P<0.05);对重型肝炎患者进行MELD评分,MELD分值越高组,皮质醇浓度越低.结论重型肝炎患者皮质醇浓度降低,其与肝脏功能损害、病情严重程度有关,皮质醇水平与患者预后有关.
목적 탐토병독성중형간염환자혈청피질순농도적변화.방법 응용방사면역법측정50례병독성간염환자혈청피질순농도.기중중형간염환자30례,만성을형간염환자20례.동시검측환자간공능、PTA등실험실지표.결과 중형간염환자조혈청피질순농도교만성을형간염환자조저(P<0.05),교정상대조조저(P<0.05);재중형간염환자중,혈청피질순농도여PTA정현저정상관(r=0.445,P<0.05),중형간염환자혈청피질순농도여환자혈청ALT무명현상관성(P>0.05),여AST/ALT비치정현저부상관(r=-0.367,P<0.05),여환자혈청총담홍소무명현상관성(P>0.05);중형간염환자사망조적혈청피질순농도명현저우존활조(P<0.05);대중형간염환자진행MELD평분,MELD분치월고조,피질순농도월저.결론 중형간염환자피질순농도강저,기여간장공능손해、병정엄중정도유관,피질순수평여환자예후유관.
Objective To investigate the profile of serum cortisol levels in patients with severe hepatitis. Methods Fifty patients with viral hepatitis(including 30 severe hepatitis patients and 20 chronic hepatitis B. patients) were enrolled in this present study. Serum cortisol concentration was tested using radioimmunoassay. Furthermore, liver function, coagulation and other related laboratory indices were also determined. Results Serum cortisol concentration of severe hepatitis group was lower than that of chronic hepatitis B. group (P<0.05) and lower than that of healthy controls (P<0.05). serum cortisol concentration of severe hepatitis patients was significantly positively correlated with PTA (r=0.445, P< 0.05);serum cortisol concentration has no relation with ALT in patients with severe hepatitis(P>0.05), and serum cortisol concentration was significantly negatively correlated with the ratio of AST/ALT in patients with severe hepatitis(r=-0.367, P<0.05) ;No significant relationship was found between serum cortisol concentration and total Bilirubin(P>0.05) ;Serum cortisol concentration in death group of severe hepatitis was lower than that in survival group of severe hepatitis(P<0.05) ;Of severe hepatitis patients with MELD score, the higher MELD score, the lower the cortisol concentration. Conclusion Cortisol concentration decreased in patients with severe hepatitis, which was related to functional liver reserve and disease severity. Cortisol can be related to the prognosis of severe hepatitis patients.