CAJ | 학술논문

目的观察雌激素受体β(ER-β)在膀胱癌中的表达及其与临床病理特征的关系,探讨其临床意义.方法采用免疫组织化学SP法检测ER-β蛋白在146例膀胱尿路上皮癌和25例正常膀胱黏膜中的表达.结果 ER-β蛋白在膀胱癌组织中阳性表达率为44.5%,在正常膀胱黏膜组织阳性表达率为20.0%,差异有统计学意义(P＜0.05).ER-β的表达率随着膀胱癌病理分级和临床分期的升高而增高(P＜0.05),而且与患者性别明显相关,女性阳性率显著高于男性患者(P＜0.05).结论 ER-β在膀胱癌组织中表达有明显的性别差异,且与膀胱癌的分化和浸润性进展密切相关,提示ER-β蛋白可能在膀胱癌的发生发展中起重要作用.
목적 관찰자격소수체β(ER-β)재방광암중적표체급기여림상병리특정적관계,탐토기림상의의.방법 채용면역조직화학SP법검측ER-β단백재146례방광뇨로상피암화25례정상방광점막중적표체.결과 ER-β단백재방광암조직중양성표체솔위44.5%,재정상방광점막조직양성표체솔위20.0%,차이유통계학의의(P＜0.05).ER-β적표체솔수착방광암병리분급화림상분기적승고이증고(P＜0.05),이차여환자성별명현상관,녀성양성솔현저고우남성환자(P＜0.05).결론 ER-β재방광암조직중표체유명현적성별차이,차여방광암적분화화침윤성진전밀절상관,제시ER-β단백가능재방광암적발생발전중기중요작용.
Objective To investigate the expression of estrogen receptor beta (ER-β) in bladder urothelial carcinoma and to explore its clinical significance.Methods Immunohistochemical SP method was employed to detected the expression of ER-β in bladder cancer tissue ( 146 cases) and the normal controls (25 cases).In addition,clinicopathological data of them were analyzed.Results The positive expression rate of ER-β in bladder cancer tissue was 44.5%,but low positive expression rate (20.0% )was found in normal bladder tissue.The expression of ER-β was markedly associated with tumor pathological grade and clinical stage ( P＜0.05).Moreover,the expression of ER-β was observed more frequently in female (59.6%) than male (37.4%) (P＜0.05 ).Conclusion The sex difference in expression of ER-β is associated with differentiation and invasion in bladder urothelial carcinoma,it implies that ER-β might play important roles in the development and progression of bladder cancer.