中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2011年
1期
22-24
,共3页
邵良荣%邵杰%肖丽华%季建伟
邵良榮%邵傑%肖麗華%季建偉
소량영%소걸%초려화%계건위
组织多肽特异性抗原%神经元特异性烯醇化酶%癌胚抗原%细胞角蛋白21-1%肺癌%肿瘤标志物
組織多肽特異性抗原%神經元特異性烯醇化酶%癌胚抗原%細胞角蛋白21-1%肺癌%腫瘤標誌物
조직다태특이성항원%신경원특이성희순화매%암배항원%세포각단백21-1%폐암%종류표지물
Tissue%Neuron- specific endase%Carcinoma embryonic antigen%Serum cytokeratin 21 - 1 fragment%Lung cancer%Tumor marker
目的 评价组织多肽特异性抗原(TPS)、癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)、细胞角蛋白21-1(CYFRA21-1)联合检测对肺癌的诊断价值.方法 应用电化学发光法(ECLIA)检测经病理确诊的83例肺癌、41例良性肺部疾病和30例正常体检者血清中CEA、NSE、CYFRA21-1和TPS的含量.结果 肺癌组TPS、CEA、NSE、CYFRA21-1测定水平明显高于肺良性病变组和正常对照组,差异有统计学意义(P<0.05或P<0.01);TPS、CEA、NSE、CYFRA21-1对肺癌的敏感性分别为84.34%、51.8l%、43.37%、66.26%,特异性分别为81.93%、79.52%、77.11%、80.72%,诊断符合率分别为83.13%、68.67%、69.88%、79.95%;TPS、CEA、NSE、CY-FRA21-1四项联合检测对肺癌的敏感性、特异性和诊断符合率分别为92.77%、93.97%和95.18%.结论 TPS、CEA、NSE、CYFRA21-1四项肿瘤标记物联合检测可提高肺癌检测的敏感性、特异性和准确性.
目的 評價組織多肽特異性抗原(TPS)、癌胚抗原(CEA)、神經元特異性烯醇化酶(NSE)、細胞角蛋白21-1(CYFRA21-1)聯閤檢測對肺癌的診斷價值.方法 應用電化學髮光法(ECLIA)檢測經病理確診的83例肺癌、41例良性肺部疾病和30例正常體檢者血清中CEA、NSE、CYFRA21-1和TPS的含量.結果 肺癌組TPS、CEA、NSE、CYFRA21-1測定水平明顯高于肺良性病變組和正常對照組,差異有統計學意義(P<0.05或P<0.01);TPS、CEA、NSE、CYFRA21-1對肺癌的敏感性分彆為84.34%、51.8l%、43.37%、66.26%,特異性分彆為81.93%、79.52%、77.11%、80.72%,診斷符閤率分彆為83.13%、68.67%、69.88%、79.95%;TPS、CEA、NSE、CY-FRA21-1四項聯閤檢測對肺癌的敏感性、特異性和診斷符閤率分彆為92.77%、93.97%和95.18%.結論 TPS、CEA、NSE、CYFRA21-1四項腫瘤標記物聯閤檢測可提高肺癌檢測的敏感性、特異性和準確性.
목적 평개조직다태특이성항원(TPS)、암배항원(CEA)、신경원특이성희순화매(NSE)、세포각단백21-1(CYFRA21-1)연합검측대폐암적진단개치.방법 응용전화학발광법(ECLIA)검측경병리학진적83례폐암、41례량성폐부질병화30례정상체검자혈청중CEA、NSE、CYFRA21-1화TPS적함량.결과 폐암조TPS、CEA、NSE、CYFRA21-1측정수평명현고우폐량성병변조화정상대조조,차이유통계학의의(P<0.05혹P<0.01);TPS、CEA、NSE、CYFRA21-1대폐암적민감성분별위84.34%、51.8l%、43.37%、66.26%,특이성분별위81.93%、79.52%、77.11%、80.72%,진단부합솔분별위83.13%、68.67%、69.88%、79.95%;TPS、CEA、NSE、CY-FRA21-1사항연합검측대폐암적민감성、특이성화진단부합솔분별위92.77%、93.97%화95.18%.결론 TPS、CEA、NSE、CYFRA21-1사항종류표기물연합검측가제고폐암검측적민감성、특이성화준학성.
Objective To estimate the diagnostic value of combined detection of TPS, CEA,NSE,CYFRA21 - 1 in patients with lung cancer. Methods The content of serum CEA, NSE, CY-FRA21 -1 and TPS were detected with ECLIA. There were three groups: eighty- three pathologically confirmed cases of lung cancer in lung cancer group, 41 benign pulmonary disease cases in benign pulmonary disease group and 30 normal volunteers in normal healthy group. Results The levels of serum TPS, CEA, NSE, CYFRA21 - 1 in lung cancer group were significantly higher than that in benign pulmonary disease group and normal healthy group, with a statistically significant decrease ( P < 0. 05 or P < 0.01 ). The sensitivity of TPS, CEA, NSE, CYFRA21 - 1 to lung cancer was 84. 34%, 51.81%,43.37% and 66.26%, respectively;the specificity was 81.93%, 79.52%, 77.11% and 80. 72%, respectively ,and the coincidental rate of the diagnosis was 83.13%, 68.67%, 69.88% and 79.95%, respectively. While the sensitivity, specificity and the coincidental rate of the diagnosis to lung cancer was 92.77% ,93.97% and 95.18% , respectively, with combined detection of four serum tumor markers (TPS, CEA, NSE, CYFRA21 - 1 ) in lung cancer patients. Conclusions The combined detection of the four serum tumor markers( TPS, CEA, NSE, CYFRA21 - 1 ) can improve the sensitivity, specificity and accuracy in lung cancer detection.
