CAJ | 학술논문

目的观察瑞舒伐他汀对急性脑梗死患者疗效及脑梗死体积变化的影响.方法将100例急性脑梗死患者随机分为观察组52例和对照组48例,对照组患者入院后均给予常规治疗方法,观察组在对照组治疗的基础上加服瑞舒伐他汀20 mg/d.两组均连续治疗30 d.检测两组患者神经功能缺损程度评分和脑梗死灶体积.结果治疗后观察组梗死灶体积显著低于治疗前及对照组(P均＜0.05);观察组患者神经功能缺损程度评分低于对照组(P＜0.01),Barthel指数高于对照组(P＜0.01);观察组总有效率显著高于对照组(P＜0.05).瑞舒伐他汀不良反应轻微.结论瑞舒伐他汀能加速脑梗死患者神经功能的恢复,可缩小脑梗死体积,有保护神经的作用.
목적 관찰서서벌타정대급성뇌경사환자료효급뇌경사체적변화적영향.방법 장100례급성뇌경사환자수궤분위관찰조52례화대조조48례,대조조환자입원후균급여상규치료방법,관찰조재대조조치료적기출상가복서서벌타정20 mg/d.량조균련속치료30 d.검측량조환자신경공능결손정도평분화뇌경사조체적.결과 치료후관찰조경사조체적현저저우치료전급대조조(P균＜0.05);관찰조환자신경공능결손정도평분저우대조조(P＜0.01),Barthel지수고우대조조(P＜0.01);관찰조총유효솔현저고우대조조(P＜0.05).서서벌타정불량반응경미.결론 서서벌타정능가속뇌경사환자신경공능적회복,가축소뇌경사체적,유보호신경적작용.
Objective To observe the effect of rosuvastatin on efficacy and volume changes of cerebral infarction in patients with acute cerebral infarction. Methods One hundred patients with acute cerebral infarction were randomly divided into observe group (52 cases) and control group (48 cases). The control group were given conventional treatment after admission, the observe group were given rosuvastatin(20 mg/day) treatment on the basis of conventional treatment.Both groups were treated for 30 days. Neurological deficit scores and infarct volumes of two groups were recorded. Results After treatment, the infarct volume of the observe group was significantly lower than before treatment and the control group(P all＜0.05),the neurologic impairment score of the observe group was lower than the control group(P＜0.01),the Barthel index of the observe group was higher than the control group(P＜0.01),the total effective rate of the observe group was significantly higher than the control group (P＜0.05). The side effects of rosuvast were minor. Conclusions Rosuvastatin can accelerate the recovery of neurological function in patients with cerebral infarction, can reduce infarct size and has the effect of nerve protection.