CAJ | 학술논문

目的探讨药物性肝损伤的病因及临床特点,以提高临床医师对该病的认识.方法对1998-2007年本院药物性肝损伤病例256例进行回顾性研究其所用药物、临床表现和转归等特点.结果引起肝损伤药物中中药占首位(23.8%),其次为免疫抑制剂(11.7%);临床表现主要为乏力、纳差、尿黄、恶心和右上腹不适等;治疗后88%治愈好转,病死率为6.6%.结论致肝损伤的药物种类繁多,临床表现无特异性,但病死率较高,临床医师用药时应注意监测肝功能.
목적 탐토약물성간손상적병인급림상특점,이제고림상의사대해병적인식.방법 대1998-2007년본원약물성간손상병례256례진행회고성연구기소용약물、림상표현화전귀등특점.결과 인기간손상약물중중약점수위(23.8%),기차위면역억제제(11.7%);림상표현주요위핍력、납차、뇨황、악심화우상복불괄등;치료후88%치유호전,병사솔위6.6%.결론 치간손상적약물충류번다,림상표현무특이성,단병사솔교고,림상의사용약시응주의감측간공능.
Objective To analyze the etiology and clinical features of drug-induced liver damage,in order to draw more attention to this problem. Methods Two hundred and fifty-six cases over a 10-year period were retrospectively analyzed. Results A variety of drugs,in-cluding traditional Chinese medicines(23.8% of our total cases)and immunosuppressive agent(11.7%)caused liver damage. The main clinical manifestations of it were fatigue,nausea,vomiting and jaundice. In 78.5% of our cases,the symptoms were relieved or completely disappeared, but there was still 6.6% mortality rate. Conclusion The clinical features of drug-induced liver damage are of no specificity,and the mortality of it is high. Liver function should he monitored when suspected are prescribed.