CAJ | 학술논문

磁性纳米氧化铁粒子是指直径在纳米范围的氧化铁粒子,具有化学性质稳定、血液滞留时间长、低毒性、顺磁性、生物可降解性等特点,可通过静电作用或化学作用耦联多肽、单克隆抗体、化疗药物、基因片段等靶肿瘤功能分子,因而在肿瘤影像、治疗、研究中有着广泛的应用.该文对近年来磁性纳米氧化铁粒子在肿瘤影像及治疗中的应用及进展进行了评述.
자성납미양화철입자시지직경재납미범위적양화철입자,구유화학성질은정、혈액체류시간장、저독성、순자성、생물가강해성등특점,가통과정전작용혹화학작용우련다태、단극륭항체、화료약물、기인편단등파종류공능분자,인이재종류영상、치료、연구중유착엄범적응용.해문대근년래자성납미양화철입자재종류영상급치료중적응용급진전진행료평술.
Magnetic iron oxide nanoparticles are iron oxide particles of nanometer diameter with the characters of steady chemical property, long blood retention time, low toxicity, paramagnetism and biodegradability. Due to the cross-linking to tumor-targeting ligands through electrostatic interaction or chemical coupling such as peptides, monoclonal antibodies, chemotherapeutic drugs, gene segments. They are widely used for clinical oncology imaging, therapy and investigation. This article focuses on the applications and recent developments of magnetic iron oxide nanoparticles for tumor imaging and therapy.