中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2011年
5期
601-603
,共3页
髓系细胞/代谢%膜糖蛋白类/生物合成%胸腔积液/诊断
髓繫細胞/代謝%膜糖蛋白類/生物閤成%胸腔積液/診斷
수계세포/대사%막당단백류/생물합성%흉강적액/진단
Myeloid cells/ME%Membrane glycoproteins/BI%Pleural effusion/DI
目的 检测细菌性胸腔积液患者胸水中可溶性髓系细胞触发受体-1(sTREM-1)的水平,研究sTREM-1对诊断细菌性胸腔积液的意义.方法 应用定量酶联免疫吸附法(ELISA)检测30例细菌性胸腔积液患者、33例恶性胸腔积液患者、31例结核性胸腔积液患者及28例漏出液胸水中sTREM-1,免疫浊度法检测其胸水C反应蛋白(CRP)的水平.应用受试者工作特征ROC曲线研究sTREM-1的诊断效能.结果 细菌性胸腔积液患者sTREM-1水平为[(1255.2±248.6)ng/L],较恶性胸腔积液组[(125.6±22.4)ng/L]、结核性胸腔积液组[(184.5±36.5)ng/L]及漏出液组[(92.5±20.8)ng/L]显著升高(P＜0.05),根据ROC曲线,取sTREM-1＞425 ng/L为临界值,其曲线下面积为0.953,诊断细菌性胸腔积液的灵敏度、特异度、准确率、阳性预测值和阴性预测值分别为93.3%、90.3%、91.9%、93.2%和93.3%,诊断效能高.结论 测定胸水sTREM-1水平有助于区分细菌性胸腔积液与其它原因的胸腔积液.
目的 檢測細菌性胸腔積液患者胸水中可溶性髓繫細胞觸髮受體-1(sTREM-1)的水平,研究sTREM-1對診斷細菌性胸腔積液的意義.方法 應用定量酶聯免疫吸附法(ELISA)檢測30例細菌性胸腔積液患者、33例噁性胸腔積液患者、31例結覈性胸腔積液患者及28例漏齣液胸水中sTREM-1,免疫濁度法檢測其胸水C反應蛋白(CRP)的水平.應用受試者工作特徵ROC麯線研究sTREM-1的診斷效能.結果 細菌性胸腔積液患者sTREM-1水平為[(1255.2±248.6)ng/L],較噁性胸腔積液組[(125.6±22.4)ng/L]、結覈性胸腔積液組[(184.5±36.5)ng/L]及漏齣液組[(92.5±20.8)ng/L]顯著升高(P＜0.05),根據ROC麯線,取sTREM-1＞425 ng/L為臨界值,其麯線下麵積為0.953,診斷細菌性胸腔積液的靈敏度、特異度、準確率、暘性預測值和陰性預測值分彆為93.3%、90.3%、91.9%、93.2%和93.3%,診斷效能高.結論 測定胸水sTREM-1水平有助于區分細菌性胸腔積液與其它原因的胸腔積液.
목적 검측세균성흉강적액환자흉수중가용성수계세포촉발수체-1(sTREM-1)적수평,연구sTREM-1대진단세균성흉강적액적의의.방법 응용정량매련면역흡부법(ELISA)검측30례세균성흉강적액환자、33례악성흉강적액환자、31례결핵성흉강적액환자급28례루출액흉수중sTREM-1,면역탁도법검측기흉수C반응단백(CRP)적수평.응용수시자공작특정ROC곡선연구sTREM-1적진단효능.결과 세균성흉강적액환자sTREM-1수평위[(1255.2±248.6)ng/L],교악성흉강적액조[(125.6±22.4)ng/L]、결핵성흉강적액조[(184.5±36.5)ng/L]급루출액조[(92.5±20.8)ng/L]현저승고(P＜0.05),근거ROC곡선,취sTREM-1＞425 ng/L위림계치,기곡선하면적위0.953,진단세균성흉강적액적령민도、특이도、준학솔、양성예측치화음성예측치분별위93.3%、90.3%、91.9%、93.2%화93.3%,진단효능고.결론 측정흉수sTREM-1수평유조우구분세균성흉강적액여기타원인적흉강적액.
Objective To investigate the value of soluble triggering receptor expressed on myeloid cells-1(sTREM-1) in the diagnosis of bacterial pleural effusion. Methods The levels of sTREM-1 in pleural effusion were determined in 30 patients with bacterial pleural effusion, 33 patients with malignant pleural effusion,31 patients with tuberculous pleural effusion and 28 patients with transudate by quantitative ELISA assay. The levels of CRP in pleural effusion were assayed using immunonephelometry method. The diagnostic value was assessed by receiver operating characteristic ROC curve analysis. Results The levels of sTREM-1［(1255.2±248.6)ng/L］ in bacterial pleural effusion were significantly higher than those in malignant ［（125.6±22.4）ng/L］, tuberculous［（184.5±36.5）ng/L］ and transudate groups［（92.5±20.8）ng/L］ (P＜0.05). For ROC curve, when the cut off value of sTREM-1 was set at 425 ng/L, the sensitivity , specificity ,accuracy, positive predictive value and negative value was 93.3%,90.3%,91.9%,93.2% and 93.3%, respectively. Conclusions Detection of sTREM-1 in pleural effusion is helpful to differentiate pleural effusion of bacterial origin from those with other etiologies.
