CAJ | 학술논문

目的分析肌炎/皮肌炎(PM/DM)合并纵隔气肿的临床特点、治疗和转归,探求其发病机制和影响预后的因素.方法回顾性分析了96例PM/DM患者的临床资料,详细描述了5例合并纵隔气肿患者的临床资料.复习英文文献报道的24例PM/DM并发纵隔气肿的病例特点.结果 5例合并纵隔气肿,发生纵隔气肿前都有肺部感染.29例(含本文5例)合并纵隔气肿病例中,10例应用甲基泼尼松龙冲击,4例存活,6例死亡;9例应用环孢素治疗,其中7例存活,2例死亡.结论 PM/DM患者合并纵隔气肿的发病机制中,感染也是一个重要因素.甲基强的松龙冲击治疗效果差,而环孢素治疗有效.
목적 분석기염/피기염(PM/DM)합병종격기종적림상특점、치료화전귀,탐구기발병궤제화영향예후적인소.방법 회고성분석료96례PM/DM환자적림상자료,상세묘술료5례합병종격기종환자적림상자료.복습영문문헌보도적24례PM/DM병발종격기종적병례특점.결과 5례합병종격기종,발생종격기종전도유폐부감염.29례(함본문5례)합병종격기종병례중,10례응용갑기발니송룡충격,4례존활,6례사망;9례응용배포소치료,기중7례존활,2례사망.결론 PM/DM환자합병종격기종적발병궤제중,감염야시일개중요인소.갑기강적송룡충격치료효과차,이배포소치료유효.
Objective To analyze the clinical characteristics of pneumomediastinum in patients with dermatomyositis and polymyositis for demonstrating its pathogenesis and for predicting its prognosis. Methods The clinical records of 96 patients with PM/DM were reviewed, focusing on for perdicting its pneumomediastinum. Five patients with pneumomediastinum are described in detail. Case reports of pneumomediastinum in PM/DM in English publications are reviewed. Results Five DM cases complicated by pneumomediastinum all had lung infections. Twenty-nine cases (including our five cases) of DM/PM with pneumomediastinum have taken methylprednisolone, four cases alive, and six died. Nine cases have taken CsA,seven cases alive and two died. Conclusion The infections was strongly suspected as being responsible for the pneumomediastinum. Methylprednisolone has poor effect. CsA can be an effective therapeutic agent in PM/DM.