CAJ | 학술논문

本文根据I型变态反应在流行性出血热免疫学发病机理中的重要作用,应用抗过敏疗法对比观察了301例EHF早期患者(治疗组143例;对照组.158例).观察结果证明,抗过敏疗法治疗组具有退热快、尿蛋白消失早、BUN水平上升底、血小板回升快、越期率高等优点;同时还具有明显地降低血清IgE和组织胺含量、以及纠正cAMP和cGMP失调的作用.上述各项指标同对照组比较,有显著性差异(P＜0.05～0.01).
본문근거I형변태반응재류행성출혈열면역학발병궤리중적중요작용,응용항과민요법대비관찰료301례EHF조기환자(치료조143례;대조조.158례).관찰결과증명,항과민요법치료조구유퇴열쾌、뇨단백소실조、BUN수평상승저、혈소판회승쾌、월기솔고등우점;동시환구유명현지강저혈청IgE화조직알함량、이급규정cAMP화cGMP실조적작용.상술각항지표동대조조비교,유현저성차이(P＜0.05～0.01).
The Study group consisted of 143 cases with epidemic hemorrhagic fever(EHF) treated with combined anti-allergic therapy (cytosine,arabinoside,aspirin,anisodaminine bydroehloride and cyproheptadine bydroohloride),but only symptomatic and supportive therapy was given in 138 eases as control group.As compared wilh the control group,cases in the study group showed much more improvement in clinical symptoms and signs, the body temperature was lowered rapidly, albuminuria disappeared, blood plateless count returned to normal,and patients having no shock and oliguria stages accounted for 93.9% and 98.4% rospectively.All eases were cured.Both serum IgE level and histamine level were remarkably decreased,meanwhile the metabolic disturbance of cAMP and eGMP level was put righ.The therapeutic results of the study group were apparently different from those 0f the conirol group(p＜O.05～O.01). The mechanism of the combined therapy is discussed.