CAJ | 학술논문

目的评价新型低弹β钛合金内置物对大鼠骨质疏松骨折愈合的作用及应力遮挡效应.方法 40只SD雌性大鼠去势,建立骨质疏松动物模型,采用Utvag方法制备双股骨骨折模型,选用弹性模量分别为110 Gpa和33 Gpa的钛合金制成髓内针固定骨折,左侧为高弹组,右侧为低弹组,分别于术后6,12周行组织学、Micro-CT及牛物力学检测,Micro-CT检测指标为骨小梁的体积(BV)、样本体积(TV)及骨体积分数(BVF),牛物力学检测指标为最大载荷,比较两种弹性模昔钛合金置入物对骨折骨痂形成及力学特性的影响,并进行统计学分析.结果低弹组显示了更多的胶原及骨痂形成,骨小梁更厚,板层骨排列更加规则.骨质疏松大鼠股骨骨折后6周,低弹组ROI 1区TV值高于高弹组(P<0.05),其余差异无统计学意义;术后12周,低弹组R0I 1区TV值、BV值均高于高弹组(P<0.05).低弹组ROI 2区BV高于高弹组(P<0.05).生物力学检测提示低弹组最大载倚优于高弹组.结论新型低弹β钛合金内置物有利于大鼠骨质疏松骨折早期骨痂的形成,并提高骨折愈合的远期质量,减少了骨折同定节段的骨量丢失.
목적 평개신형저탄β태합금내치물대대서골질소송골절유합적작용급응력차당효응.방법 40지SD자성대서거세,건립골질소송동물모형,채용Utvag방법제비쌍고골골절모형,선용탄성모량분별위110 Gpa화33 Gpa적태합금제성수내침고정골절,좌측위고탄조,우측위저탄조,분별우술후6,12주행조직학、Micro-CT급우물역학검측,Micro-CT검측지표위골소량적체적(BV)、양본체적(TV)급골체적분수(BVF),우물역학검측지표위최대재하,비교량충탄성모석태합금치입물대골절골가형성급역학특성적영향,병진행통계학분석.결과 저탄조현시료경다적효원급골가형성,골소량경후,판층골배렬경가규칙.골질소송대서고골골절후6주,저탄조ROI 1구TV치고우고탄조(P<0.05),기여차이무통계학의의;술후12주,저탄조R0I 1구TV치、BV치균고우고탄조(P<0.05).저탄조ROI 2구BV고우고탄조(P<0.05).생물역학검측제시저탄조최대재의우우고탄조.결론 신형저탄β태합금내치물유리우대서골질소송골절조기골가적형성,병제고골절유합적원기질량,감소료골절동정절단적골량주실.
Objective To investigate the effects of a novel |3 titanium fixation with high strength and low elastic modulus on bone healing of osteoporotic fracture and its effects on stress shielding.Methods Forty female Sprague-Dawley rats were oophorectomized before establishment of femur fracture model.The fracture of left femur was stabilized by titanium alloy pin with high elastic modulus (110 Gpa,high elasticity modulus group) and the fracture of right femur by titanium alloy pin with low elastic modu-lus (30 Gpa, low elasticity modulus group).Six and 12 weeks later, the bone volume (BV) , total vol-ume (TV) and bone volume fraction (BVF) were detected by Micro-CT, and the maximum load was de-tected by biomechanical test.The effects of two titanium alloy pins on formation of bony calluses and me-chanical properties of bones were compared.Results Compared with the low elasticity modulus group, more collagen and bony callus, thicker bone trabeculae and more regular lamellar bone were found in the high elasticity modulus group.In low elasticity modulus group, TV (ROI1) was increased obvious-ly at week 6, with no statistical differences in BV (ROI 1), BV (ROI 2) and maximum load between two groups (P < 0.05).TV and BV in region ROI 1 in the low elasticity modulus group were significantly higher than that in high elasticity modulus group (P < 0.05) , while BV in region ROI 2 in low elasticity modulus group was significantly higher than that in high elasticity modulus group at week 12 postoperative-ly (P<0.05).Biomechnical test indicated that the maximum load in low elasticity modulus group was higher than that in high elasticity modulus group.Conclusions The novel B titanium alloy with high strength and low elastic modulus helps reduce effects of stress shielding, diminish bone resorption, in-crease the fibrous callus formation at the initial phase and improve the quality of bone healing at the later phase.