CAJ | 학술논문

恶性黑色素瘤是一种恶性程度极高的皮肤肿瘤,病人发生转移后应用传统治疗方法很难达到有效治疗.自从恶性黑色素瘤的肿瘤抗原表位被发现后,恶性黑色素瘤的免疫治疗就开始成为研究热点.过继性细胞治疗临床应用研究在近几年内得到快速发展,其中疗效最好的当属肿瘤浸润淋巴细胞(TIL)回输治疗,其治疗有效率可以达到70%以上.同时,各种用于调节免疫系统的单克隆抗体药物以及信号传导阻滞剂的研究也在快速发展,这些研究为恶性黑色素瘤的免疫治疗提供了新思路.多种不同作用机制的药物疗效将在不久的将来得到证实,尤其是抗细胞毒性T细胞相关抗原4(CTLA-4)抗体的ipilimumab以及高选择性B型有丝分裂原激活的蛋白激酶依粘性激酶的激酶(BRAF)阻断剂PLX4032.
악성흑색소류시일충악성정도겁고적피부종류,병인발생전이후응용전통치료방법흔난체도유효치료.자종악성흑색소류적종류항원표위피발현후,악성흑색소류적면역치료취개시성위연구열점.과계성세포치료림상응용연구재근궤년내득도쾌속발전,기중료효최호적당속종류침윤림파세포(TIL)회수치료,기치료유효솔가이체도70%이상.동시,각충용우조절면역계통적단극륭항체약물이급신호전도조체제적연구야재쾌속발전,저사연구위악성흑색소류적면역치료제공료신사로.다충불동작용궤제적약물료효장재불구적장래득도증실,우기시항세포독성T세포상관항원4(CTLA-4)항체적ipilimumab이급고선택성B형유사분렬원격활적단백격매의점성격매적격매(BRAF)조단제PLX4032.
Melanoma is the most serious type of skin cancer and hard to be cured by traditional therapy when metastasis occurs in the patients. Since the immunogenicity of the melanoma was discovered,the biological and immune therapy for this tumour became a hot spot of research. The clinical research on adoptive cell transfer has developed rapidly in recent years and the most remarkable effecs obtained were the infusing of autotumor infiltrating lymphocyte with over a 70% partial response. In the mean time,the research on monoclonal antibodies and signalling pathway inhibitor has been progressing quickly. These researchs have provided new approaches to the biological and immune therapy. The effects of various medicine with different mechanisms will be demonstrated in the near future,especially ipilimumab,the anti-CTLA-4 monoclonal antibody and PLX4032,an highly selective inhibitor of BRAF.