CAJ | 학술논문

为了明确神经肽Y(NPY),生长抑素(SOM)和降钙素调节基因相关肽(CGRP)能神经与先天性巨结肠症(HD)的关系,采用Sternberger报道的免疫组织化学方法.了解到HD狭窄段内缺乏NPY、SOM和CGAP能神经元胞体,但三种纤维明显增生增粗,并出现小神经干,且NPY、SOM和CGRP能神经支配紊乱,与HD狭窄段痉挛及蠕动不良有关.
위료명학신경태Y(NPY),생장억소(SOM)화강개소조절기인상관태(CGRP)능신경여선천성거결장증(HD)적관계,채용Sternberger보도적면역조직화학방법.료해도HD협착단내결핍NPY、SOM화CGAP능신경원포체,단삼충섬유명현증생증조,병출현소신경간,차NPY、SOM화CGRP능신경지배문란,여HD협착단경련급연동불량유관.
Aim:To understand the relationship between Hirschsprung's disease(HD)and neu ropeptide Y.calcitonin gene-related peptide(CGRP)and somatostatin(SOM)peptidergic nerves respectively.Method:Using the immunohistochemical essay reported by Sternberger.Results: The results showed that NPY，CGRP and SOM peptidergic nerve fibers are proliferative in the a gagnlionic segment of congenital megacolon，and some fiber bundles are found with absence of nerve cells.Conclusion:These abnormalities may have correlations with the pathophysiology(e.g. Spasm and absence of propagation of aganglionic segment)of HD.